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Colony stimulating factor receptor CSF R or
2019-08-24
Colony stimulating factor-1 receptor (CSF-1R or cFMS) is a type III receptor tyrosine kinase. It is activated by binding with CSF-1 and IL-34, which stimulates differentiation, proliferation, survival and migration of monocyte-macrophage lineage cells., , , Also, macrophages produce inflammatory me
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Furthermore many intermediate plants did not
2019-08-24
Furthermore, many intermediate plants did not show additive combinations of parental allozymes, which would be expected in F1 hybrids. The absence of some characteristic parental bands suggests that sexual reproduction has occurred among the hybrid plants. Genetic variations within and among the int
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Noteworthy the transient downregulation of the regulatory CK
2019-08-24
Noteworthy, the transient downregulation of the regulatory CK2β subunit reduces HSP27 expression in all the three different human cell lines (Fig. 2b). Similarly, the downregulation of one of the two catalytic subunits, CK2α or CK2α′, is sufficient to affect HSP27 expression without affecting other
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Although BPA has been proven to cause many health issues
2019-08-24
Although BPA has been proven to cause many health issues such as obesity and neurological toxicity (Rubin, 2011), the effects and mechanisms of BPA on the human tumorigenesis and cancer development are still not well illustrated. In the present study, we found that 10 to 10M BPA significantly promot
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Renal injury by cisplatin has been associated with
2019-08-24
Renal injury by cisplatin has been associated with oxidative stress, inflammation, and apoptosis (Francescato et al., 2007, Iseri et al., 2007, Kiymaz et al., 2008, Ueki et al., 2012). Specifically, apoptosis is an important mode of cell death in cisplatin nephrotoxicity, and many studies including
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GYKI 52466 dihydrochloride A putative SHBG receptor SHBG R h
2019-08-24
A putative SHBG GYKI 52466 dihydrochloride (SHBG-R) has been postulated for about thirty years [66], [69], [70]. The characterization of this receptor has been researched by several groups. There are different ideas on how this receptor works. On the one hand Fortunati et al. provide evidence that S
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Concholepas concholepas our model species
2019-08-24
Concholepas concholepas, our model species for this study, is a marine gastropod found along the Chilean coast that has become commercially important [25], [26], [27]. Until now, the main focus of immunology related to C. concholepas is the production of a novel hemocyanin that has been useful for t
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It has only recently been appreciated that antigen activated
2019-08-23
It has only recently been appreciated that antigen-activated 2-Palmitoylglycerol undertake two additional transient migrations during the early stages of T-dependent antibody responses. In the first of these, antigen-activated B cells migrate rapidly (within 2–3h) to the outer regions of the follic
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While SCF E ligase activity was reconstituted with
2019-08-23
While SCF E3 ligase activity was reconstituted with recombinant proteins two decades ago, the ability to probe APC/C was limited until recently because of its behemoth size. Human APC/C is a 1.2-MDa assembly comprised of 19 core subunits (one each of nine different APC subunits, and two each of five
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The present study was set
2019-08-23
The present study was set to characterise the DNMT gene orthologs and describe the expression patterns of these genes during seed development in natural diploid apomict B. divaricarpa and diploid sexual B. stricta. Material and methods Results The B. stricta genome v1.2, was sequenced and ass
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Collagen alignment can contribute to tissue stiffening Malik
2019-08-23
Collagen alignment can contribute to tissue stiffening (Malik et al., 2015, Paszek et al., 2005), and ECM stiffness in turn is a powerful activator of integrin function (Levental et al., 2009). These findings highlight the contribution of the mechanical properties of the ECM to signal transduction.
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Acknowledgments The authors thank Dr Vladimir Poltoratsky an
2019-08-23
Acknowledgments The authors thank Dr. Vladimir Poltoratsky and Zhihui Xiao for their help with the in vitro FRET assay. Support for this research was provided by Saint John’s University. Introduction We predicted the existence of endothelium-derived contractile factors (EDCFs) in 1982 [1]. In 1
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The idea of boron based pro estrogens has been utilized
2019-08-23
The idea of boron-based pro-estrogens has been utilized before; in previous studies, the selective estrogen receptor modulators (SERMs) tamoxifen and endoxifen have been masked as boronate esters.13, 14, 15 Tamoxifen and endoxifen both target ERα as therapies for breast cancer. The previous work foc
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br Results Patient disease and treatment characteristics of
2019-08-23
Results Patient, disease, and treatment characteristics of the study cohort are described in Table 1. All patients were stage IIIA with pathologically documented N2 disease per AJCC 7th edition. EP4 nuclear staining 0–1 versus 2+ was significantly associated with overall survival (OS) (44.3 vs.
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One of the most fundamental distinctions between
2019-08-22
One of the most fundamental distinctions between Ub signals is substrate monoubiquitination versus polyubiquitination. With the exception of the E2, UBE2W, which represents a special case because it GX-674 only ubiquitinates the flexible N-termini of substrates [5], [6], [20], most examples of mono