Direct cell reprogramming technology is

2018-10-20

Direct cell-reprogramming technology is based on the dominant action of cell-lineage transcription factors (TFs) in converting adult somatic cells into different cell types (Graf and Enver, 2009). This technique represents a promising avenue in the field of regenerative medicine, with the potential

Existing treatments for myelomeningocele repair consist

2018-10-20

Existing treatments for myelomeningocele repair consist of pre- or post-natal surgical closure of the defect. Prenatal intervention has been shown to be more effective than postnatal surgery because it can prevent or ameliorate sequels (Adzick et al., 2011; Adzick et al., 1998; Meuli et al., 1997; M

To reprogram patient cells we adopted the most feasible and

2018-10-20

To reprogram patient cells, we adopted the most feasible and safest protocol using a patient cell source that is easy to obtain, PB-MNCs, and an integration-free reprogramming strategy based on SeV vectors. PB-MNCs were chosen, as blood collection is common in patient follow-up and is minimally inva

Recently we found that vesicular monoamine transporter VMAT

2018-10-20

Recently, we found that vesicular monoamine transporter 2 (VMAT2) regulates monoamine (including dopamine) storage by acting as a negative regulator, such that high monoamine levels inhibit the progression from Pdx1+ pancreatic progenitor Nanaomycin A to Neurog3+ endocrine progenitor cells of ESC-de

order GDC-0879 Our study made use of single cell transcripti

2018-10-20

Our study made use of single-cell transcriptional profiling to define the heterogeneity of hormone-producing order GDC-0879 derived from hPSCs. The technology is a powerful tool that allowed us to determine the percentage of various hormone-producing cells and shifts in this distribution upon treatm

FOXP labels striatal precursors and differentiated MSNs Dell

2018-10-20

FOXP1 labels striatal precursors and differentiated MSNs (Delli et al., 2013). Diverse studies thus far have attempted to pre-differentiate stem cycloheximide solubility into transplantable striatal progenitors or MSNs by using various kinds of differentiation protocols. Human ESCs were demonstrate

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2018-07-29