• Extending the issue of the species differences

  2021-10-19

  

  Extending the issue of the species differences, the role of neuroestradiol in the preovulatory GnRH/LH surge might be specific to primates or species with a luteal phase. For example, animals with a true luteal phase, such as monkeys and sheep, exhibit a long preovulatory GnRH surge, lasting well af

• To maintain low Glu concentrations in the synaptic

  2021-10-19

  

  To maintain low Glu concentrations in the synaptic cleft below the affinity of its receptors, this amino Candesartan is rapidly removed from the extracellular space by a family of sodium-dependent high-affinity transport systems located mainly in the plasma membrane of perisynaptic astrocytes, and i

• In this study for the first

  2021-10-19

  

  In this study, for the first time: 1) the electrochemical glutamate oxidase-based biosensor was optimized for the determination of low micromolar glutamate concentrations; 2) the algorithm of the analysis of exocytotic and transporter–mediated glutamate release was developed; 3) the comparative anal

• Free d glutamate also has been found in

  2021-10-19

  

  Free d-glutamate also has been found in various tissues of invertebrates and vertebrates including mammals (Han et al., 2011; Ariyoshi et al., 2017), fish (Kera et al., 2001) amphibians (Kera et al., 2001), birds (Kera et al., 2001), mollusks (Tarui et al., 2003; Patel et al., 2017) and arthropods (

• The bFGF induced upregulation of both GR

  2021-10-19

  

  The bFGF-induced upregulation of both GR and MR levels observed in our study raises a question regarding whether the simultaneous augmentation of the two receptors has a physiological and/or medical significance. It has been suggested that MR stimulates intracellular signaling pathways to minimize s

• The GH family has potential applications in various

  2021-10-18

  

  The GH family has potential applications in various industries. A putative ORF encoding α-galactosidase, namely GalR, with a low identical match and e-value and high query coverage in the metagenome was selected because it demonstrated considerable activity. GalR shared 65% identity with the GH 27 p

• Isoflurane administration during i t procedures can complica

  2021-10-18

  

  Isoflurane administration during i.t. procedures can complicate the interpretation of our results since isoflurane has been shown to have both neuroprotective and neurotoxic effects (Jiang et al., 2017). Isoflurane pretreatment has been implicated as having protective effects in ischemia in animal m

• Similarly spectrophotometric titrations were carried out und

  2021-10-18

  

  Similarly, spectrophotometric titrations were carried out under conditions identical to those used for the fluorescence titrations. exhibited a predominant Sulindac band at around 493 nm. The titrations with all G-quadruplex DNAs resulted in a hypochromic effect along with a bathochromic shift of

• According to the World Health Organization the average globa

  2021-10-18

  

  According to the World Health Organization, the average global intake of fat has increased by 20 g per person over the last half-century [21]. However, not all fats are the same and it is now well established that saturated and unsaturated fats, as well as trans fats, can act in opposing ways to inf

• br Fenton reaction based nanomaterials for ferroptosis

  2021-10-18

  

  Fenton reaction-based nanomaterials for ferroptosis In Fenton reaction, H2O2 is converted by Fe2+ or Fe3+ to highly oxidative ROS (Eqs. (1) and (2)), which is commonly used to catalyze the degradation of refractory organics [34]. Since the tumor microenvironment is characterized by low acidity an

• br FAAH regulation of ECB signaling ECBs are fatty

  2021-10-18

  

  FAAH regulation of ECB signaling ECBs are fatty dextromethorphan hydrobromide amides and monoacylglyerols functioning as neuromodulator lipids that exhibit rapid (within seconds) on-demand biosynthesis in response to neuronal activation, and are subsequently degraded by specialized catabolic enzy

• While more detailed molecular studies on the mechanistic bas

  2021-10-18

  

  While more-detailed molecular studies on the mechanistic basis for heightened H3 receptor function in PAE rats are underway, we have also been exploring whether PAE alters other markers of histaminergic neurotransmission in affected brain regions. One question is whether PAE affected the number of h

• A recent novel and important

  2021-10-18

  

  A recent novel and important finding is that YAP connects cellular growth with anabolism; YAP suppresses the transcriptional induction of genes which importantly regulate gluconeogenesis in the liver; namely glucose-6-phosphatase catalytic subunit (G6PC) and phosphoenolpyruvate carboxykinase 1 (PCK1

• To identify factors associated with being

  2021-10-18

  

  To identify factors associated with being HCV-unaware, univariable and multivariable logistic model were used, odds ratios, 95% confidence intervals and p-values were reported. We included in the multivariable model factors associated with unawareness of HCV infection in univariable analysis with a

• br Materials and methods br Results br Discussion

  2021-10-18

  

  Materials and methods Results Discussion Metabolic abnormalities and systemic immune dysfunctions are common during HIV infection and/or antiretroviral therapy. Although some transcriptomic studies of HIV infection have revealed global changes in the mRNA and microRNA expression profiles (R

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