• Docetaxel in Next-Generation Gastric Cancer Assembloid Re...

  2025-09-29

  Explore how Docetaxel, a leading microtubule stabilization agent, is transforming gastric cancer research using advanced assembloid models. This in-depth article reveals unique strategies for dissecting the tumor microenvironment and drug resistance—insights not found in standard reviews.

• BMN 673 (Talazoparib): Precision PARP-DNA Trapping for PI...

  2025-09-28

  Explore how BMN 673 (Talazoparib), a potent PARP1/2 inhibitor, advances precision cancer therapy by exploiting DNA repair deficiencies and PI3K pathway modulation. This in-depth review uncovers novel mechanistic insights and translational strategies beyond standard PARP inhibition.

• HyperScribe™ T7 High Yield RNA Synthesis Kit: Unlocking E...

  2025-09-27

  Explore how the HyperScribe T7 High Yield RNA Synthesis Kit revolutionizes in vitro transcription RNA workflows, enabling advanced studies in RNA modification, oocyte maturation, and epitranscriptomics. Discover unique insights into post-transcriptional regulation and experimental flexibility for next-generation RNA research.

• 2'3'-cGAMP (sodium salt): Molecular Precision in STING-Dr...

  2025-09-26

  Explore the unique molecular mechanisms and translational potential of 2'3'-cGAMP (sodium salt) in STING-mediated innate immune responses. This in-depth article uncovers nuanced insights for cancer immunotherapy and antiviral research beyond existing analyses.

• Dissecting DNA Fragmentation: Advanced Applications of th...

  2025-09-25

  Explore the advanced mechanistic and translational applications of the One-step TUNEL Cy3 Apoptosis Detection Kit in apoptosis and cell death pathway research. This article uniquely integrates emerging insights from pyroptosis studies and provides expert guidance for maximizing the kit’s power in both routine and cutting-edge experimental models.

• Bufuralol Hydrochloride: Unraveling β-Adrenergic Blockade...

  2025-09-24

  Explore how Bufuralol hydrochloride, a non-selective β-adrenergic receptor antagonist, is redefining cardiovascular pharmacology research through integration with advanced human organoid and iPSC models. This article uniquely examines its mechanistic and pharmacokinetic roles in translational β-adrenergic modulation studies.

• Optimizing mRNA Assays: EZ Cap™ Firefly Luciferase mRNA (...

  2025-09-23

  Explore how EZ Cap™ Firefly Luciferase mRNA (5-moUTP) advances in vitro transcribed capped mRNA applications for precise mRNA delivery and translation efficiency assays. This article provides practical insights into minimizing innate immune activation and maximizing poly(A) tail mRNA stability in mammalian systems.

• br Autophagy inducers Macroautophagy is

  2025-04-22

  

  Autophagy inducers Macroautophagy is often seen as a cellular process capable of increasing the fitness of Sulfo-NHS-Biotin and overcome resistance to several forms of stress [9], [10]. As discussed above, it has been proposed by several authors that an effective strategy for enhancing sensitivi

• HotStart™ 2X Green qPCR Master Mix Introduction The first us

  2025-04-22

  

  Introduction The first use of the term “autophagy” by a French physiologist, M. Anselmier, in a short article describing the effects of fasting in mice published in 1859, took place almost a century before Christian De Duve described it from a mechanistic point of view in a symposium on lysosomes i

• br Introduction Human esophageal carcinoma is one of

  2025-04-22

  

  Introduction Human esophageal carcinoma is one of the most frequently diagnosed cancers, ranked as the eighth leading causes of cancer-related mortality worldwide. Esophagus squamous cell carcinoma (ESCC) is the most common histological type of esophageal carcinomas, especially with a higher inci

• Previous studies have demonstrated ATR inhibition

  2025-04-18

  

  Previous studies have demonstrated ATR inhibition is effective for treating cancers combining with chemotherapies in lung adenocarcinoma, gastric cancer, HER2 positive breast cancer and chronic lymphocytic leukemia EZ Cap™ Cy5 Firefly Luciferase mRNA (5-moUTP) to enhance chemotherapy sensitivity [[

• Functional enhancers are often composed of

  2025-04-17

  

  Functional enhancers are often composed of binding motifs of multiple key transcription factors to confer spatial and temporal regulation of genes in a certain context. In the uterus, the difference between the number of genes that have associated PGR occupancy and that of progesterone responsive ge

• br Conclusions and future direction ER

  2025-04-17

  

  Conclusions and future direction ER(−)/PgR(+) breast cancers have a distinct clinical course, response to treatment, and molecular features when compared to other breast cancer types, however some of them are actually technical artifacts or consequences of too high definitions of positivity. Acco

• br Author contributions br Conflicts of interest The

  2025-04-16

  

  Author contributions Conflicts of interest The authors declare no competing financial interests. Acknowledgement This work was supported by grants from the Deutsche Forschungsgemeinschaft (Sonderforschungsbereich/Transregio 166–Project C1 and grant CA 1014/1-1 to D.C.) and the IZKF Würzbur

• Mitochondrial dysfunction resulting from mtDNA abnormalities

  2025-04-12

  

  Mitochondrial dysfunction resulting from mtDNA abnormalities may trigger retrograde signaling pathways from the mitochondrion to the nucleus, which regulate the expression of genes involved in diverse cellular processes, including metabolism, stress responses, tumor progression, nutrient sensing, li

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