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Interest in the PGE EP pathway is
2019-07-02
Interest in the PGE2/EP4 pathway is increasing given its diverse capability of regulating central nervous system activity [13]. EP4 has a protective function by reducing cerebral injury and improving functional outcome after stroke [14], and in suppressing Chlorogenic acid of inflammation [15]. The
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br The synthesis of these antagonists
2019-07-02
The synthesis of these antagonists relied heavily on Stille and Suzuki coupling reactions. The preparation of the required building blocks is presented in . Reduction of ethyl 6-bromo-2-pyridinecarboxylate with diisobutylaluminum hydride in tetrahydrofuran followed by treatment with triisopropylsi
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br Results and discussion br Conclusions In this
2019-07-02
Results and discussion Conclusions In this work, we have conjugated two thermophilic enzymes (i.e., AMY and LASPO) to iron oxide NPs through different conjugation strategies obtaining efficient biocatalysts. We have demonstrated that these NP-enzyme systems can be successfully activated by an
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br Experimental br Results and discussion br Conclusions
2019-07-02
Experimental Results and discussion Conclusions The fungus Mucor circinelloides MUT44, previously shown to have ene-reductase activity [11], possesses ten genes coding for putative ene-reductases belonging to the Old Yellow Enzymes family. Since the reduction of CC double bonds is one of th
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The Fontan circulation When first
2019-07-01
The Fontan circulation When first described in 1971, the Fontan operation ushered in a new paradigm in the care of children born with the varied forms of complex congenital bosentan structure disease (CHD) characterized by a single effective pumping chamber.1., 2. This procedure, which creates a t
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South Africa was the first African
2019-07-01
South Africa was the first African country to implement the seven-valent pneumococcal conjugate vaccine (PCV7) in its routine infant immunisation programme (in 2009), with the novel schedule aligned to WHO\'s recommended Expanded Programme on Immunisation (EPI)—ie, a 2 + 1 schedule with doses at age
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br Genetic basis Similar to
2019-07-01
Genetic basis Similar to other arrhythmia syndromes, Brugada and early repolarization syndromes are inherited diseases that are usually transmitted in an autosomal-dominant manner [26]. To date, 13 genes have been associated with Brugada syndrome. Loss-of-function mutations in SCN5A, encoding the
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In contrast the prevalence of BS or Brugada type
2019-07-01
In contrast, the prevalence of BS or Brugada-type ECG in Asian countries is relatively high. Type 1 ECG has been identified in 0.17% of 3907 asymptomatic Filipinos [24] and in 0.13% of 20,652 Taiwanese patients who visited the hospital for non-cardiovascular reasons [25]. Brugada-type ECG has been
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br Methods We described our strategies for ablating AF
2019-07-01
Methods We described our strategies for ablating AF in previous reports [34–36]. Therefore, we will discuss our methods for CFAE ablation, including CFAE-ablation combined with PVI, below. Results Representative cases of CFAE-ablation Conclusions Acknowledgments Characteristics of
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br Material and methods br Results
2019-07-01
Material and methods Results Discussion In our series, fracture progression was noted in 53% of the lesions and 5 patients presented with new fractures after RT. Previous studies reported on the rate of pathologic fractures after single or multifraction RT; however, they did not stratify be
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The requirements for establishing this
2019-07-01
The requirements for establishing this arrhythmia are as follows: (1) a slow pathway (or maybe a fast pathway) should not have retrograde conduction; and (2) the refractory Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO) of of the distal common pathway must be shorter than the difference in t
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br Conclusion br Funding br Conflict of interest br
2019-07-01
Conclusion Funding Conflict of interest Acknowledgments Introduction Ventricular tachyarrhythmias (VTs) are life-threatening events that result in hemodynamic compromise; therefore, patients often require immediate treatment such as electrical cardioversion. Despite appropriate manage
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Lo and colleagues also add to the evidence that
2019-07-01
Lo and colleagues also add to the evidence that MDA might need to be widened beyond school-aged children (5–14 years). Different frequencies of treatment are known to be needed for communities with different intensities of infection, but less appreciated is that different age groups need to be treat
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A partir de las consideraciones que distinguen la
2019-07-01
A partir de las consideraciones que distinguen la institucionalización formal e informal, O’Donnell hace un llamado TAK-242 molecular tener en cuenta las especificidades de las democracias de América Latina y plantea que algunas democracias han subsistido, se han mantenido en el tiempo aun con la pr
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br Since the publication of Stillbirths Series in attention
2019-06-29
Since the publication of Stillbirths Series in 2011, attention to the more than 2·6 million stillbirths that occur every year has become more visible in global and national maternal and neonatal health strategies. However, we continue to neglect the millions of women who experience not only still
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