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mitomycin Classic KS predominantly affects elderly
2018-11-15
Classic KS predominantly affects elderly people over 50 years, many of whom do not tolerate aggressive chemotherapy regimens well due to frequent comorbidity and diminished cardiovascular and bone marrow reserves. Classic KS follows an indolent course (average survival is 10–15 years) requiring long
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br Papillon Lef vre syndrome PLS
2018-11-15
Papillon–Lefèvre syndrome (PLS), also named keratosis palmoplantar with periodontopathia (OMIM 245000), was first described by Papillon and Lefèvre in 1924. The condition occurs with a frequency of 1–4:1,000,000. It is an autosomal recessive disorder which is characterized by a diffuse palmoplanta
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Wallace et al reported azoxytriazolone
2018-11-15
Wallace et al. reported azoxytriazolone (AZTO) (20) and azotriazolone (azoTO) (21) as insensitive high nitrogen compounds of energetic materials (Fig. 9) [67]. AZTO and azoTO were synthesized from NTO electrochemically, as mentioned above, and characterized by a range of techniques and compared to e
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Por eso como lo documentaron Lexartza et
2018-11-15
Por eso, como lo documentaron Lexartza et al. (2013), las violencias feminicidas de las que huyen las centroamericanas se suman al uso que se hace de sus cuerpos como testimonio de la barbarie que puede ejercerse entre los bandos que se disputan un territorio. Tal y como contaba Diana, migrante hond
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Another challenge for architects facility
2018-11-14
Another challenge for architects, facility managers, and interior designer is integrating a design specification that relates to the sense of home into a design of nursing homes, which is often based on dementia-friendly design models. Zeisel (2005), among other scholars, stated that several dementi
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Stent migration has been described either sporadically in
2018-11-14
Stent aa dutp has been described either sporadically in case reports or as an uncommon complication in larger series. Johanson et al followed 322 biliary stent placements and found 19 cases (5.9%) of distal stent migration. Another series of 297 stent placements demonstrated 11 cases (3.7%) of dist
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Findings conflict regarding the influence of ARIs on apoptos
2018-11-14
Findings conflict regarding the influence of 5ARIs on apoptosis. Bass et al. (2009) showed no effect on caspase 3 in a randomized, placebo-controlled, presurgical 30-day finasteride intervention in localized prostate cancer (N=22 in each arm). However, results of two dutasteride studies, both using
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On the basis of our genetic findings that
2018-11-14
On the basis of our genetic findings that hexokinase 2 (HK2)-mediated aerobic glycolysis, known as the Warburg effect, drives prostate tumor growth in xenograft model bearing /p53-deficient murine or human prostate cancer myeloperoxidase (Wang et al., 2014), we designed preclinical studies to deter
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The combination of romidepsin and bryostatin
2018-11-14
The combination of romidepsin and bryostatin-1 has been shown to be one of the best inducers of latent HIV-1 in primary CD4+ T LY335979 (Laird et al., 2015). However, bryostatin-1 has been showed to be involved in the modulation of NFkB and NFAT (Williams et al., 2004) and romidepsin is known to af
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ABA overall drug retention time was similar across all
2018-11-14
ABA overall drug retention time was similar across all groups (p=0·11). However, as could be expected, ABA drug retention until discontinuation for ineffectiveness was much shorter among ‘inadequate responders’ (median time in years: GR, 4·7, RR: 5·3, IR: 2·0, p=0·03). The proportion of patients wit
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Although the serum levels of some inflammatory cytokines suc
2018-11-14
Although the serum levels of some inflammatory cytokines such as TNF-α were not elevated in H. pylori-infected HFD mice, the increased abundance of Desulfovibrionaceae which can produce endotoxins and the compromised intestinal barrier s ibuprofen some doubt on the role of inflammation. In addition
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In this issue of EBioMedicine Enroth and colleagues present
2018-11-14
In this issue of EBioMedicine, Enroth and colleagues () present a comprehensive study that analyzes the individual contribution of factors related to the collection and long-term sample storage in a highly homogenous group of Northern European subjects (). Taking advantage of the sampling strategy o
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Sialylated IgG has been reported to
2018-11-14
Sialylated IgG has been reported to have anti-inflammatory properties likely mediated through interaction with the murine C-type lectin receptor SIGN-R1 (a homologue of the human DC-SIGN) and FcyRIIb (Kaneko et al., 2006; Collin and Ehlers, 2013). In our study, we found that total IgG preserved an a
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br Experimental design materials and
2018-11-14
Experimental design, materials and methods Acknowledgements The authors thank Regione Lombardia (CoVAL project, no.1723) for the financial support to the research activities. Data The FTIR of the fresh MPAB at wave numbers from 400 to 4000cm−1 are given in Fig. 1. The SEM image of prepared
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Samples were biofunctionalized using plasma
2018-11-14
Samples were biofunctionalized using plasma electrolytic oxidation on a custom-made laboratory setup. Details regarding the experimental setup can be found in [1]. Plasma electrolytic oxidation is an electrochemical process, which drives uniform growth of the titanium oxide (TiO2) layer on the surfa
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