Archives

  • 2018-07
  • 2018-10
  • 2018-11
  • 2019-04
  • 2019-05
  • 2019-06
  • 2019-07
  • 2019-08
  • 2019-09
  • 2019-10
  • 2019-11
  • 2019-12
  • 2020-01
  • 2020-02
  • 2020-03
  • 2020-04
  • 2020-05
  • 2020-06
  • 2020-07
  • 2020-08
  • 2020-09
  • 2020-10
  • 2020-11
  • 2020-12
  • 2021-01
  • 2021-02
  • 2021-03
  • 2021-04
  • 2021-05
  • 2021-06
  • 2021-07
  • 2021-08
  • 2021-09
  • 2021-10
  • 2021-11
  • 2021-12
  • 2022-01
  • 2022-02
  • 2022-03
  • 2022-04
  • 2022-05
  • 2022-06
  • 2022-07
  • 2022-08
  • 2022-09
  • 2022-10
  • 2022-11
  • 2022-12
  • 2023-01
  • 2023-02
  • 2023-03
  • 2023-04
  • 2023-05
  • 2023-06
  • 2023-07
  • 2023-08
  • 2023-09
  • 2023-10
  • 2023-11
  • 2023-12
  • 2024-01
  • 2024-02
  • 2024-03
  • 2024-04
  • If confirmed in further research

    2018-10-23

    If confirmed in further research, our findings may provide an interesting new perspective on the non-specific effects of hsp90 inhibitors and aid global efforts to reduce stunting and related negative health outcomes. Firstly, with regard to stunting, it seems that full and early coverage of vaccinations could substantially reduce stunting in low- and middle-income countries. A simulation analysis (Supplementary Table 10 and accompanying text) indicates that if all children in this study would have received BCG and DTP1 vaccination before 1month of age, a decrease in stunting of approximately 10% could be achieved. Secondly, improvement of timing of vaccinations may be reached with relatively small and achievable adaptations to the existing vaccination practice. Presently, multi-dose BCG vaccine vials are provided together with the instructions that a certain minimal percentage of the dosages should be administered, which limits health care workers in vaccinating small numbers of children (Hutchins et al., 1993). Using smaller multi-dose or single dose vials could overcome this problem and in certain situations is even the most cost-effective option (Dhamodharan and Proano, 2012). Lastly, the effects need not be limited to Africa, since stunting is a major health problem in several other world regions with suboptimal coverage and timing of vaccination, such as Latin America and South Asia (Black et al., 2013; Clark and Sanderson, 2009). Extending the interventions to these regions could further contribute to the Global Target set by the WHO to reduce stunting with 40% by 2025.
    Conclusion
    Author Contributions
    Conflict of Interest
    Funding
    Data Reporting The data were obtained from the DHS program (www.dhsprogram.com) under the condition that the authors do not pass the data to other researchers. However, other researchers can apply directly to the DHS program to obtain the data.
    Ethical Approval
    Acknowledgements The manuscript represents valid work and neither Revertant manuscript nor one with substantially similar content under our authorship has been published or is being considered for publication elsewhere. The content of the work presented here is solely the responsibility of the authors and does not necessarily represent the official views of any health organizations. The authors thank the Demographic and Health Surveys program (www.dhsprogram.org) for generously providing the data for this study.