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    • Main Text In so many ways

    2018-10-24

    Main Text In so many ways the field is stronger than ever, with terrific progress in stem cell research and discovery that has led to advances in regenerative medicine. We see research moving toward the clinic at a greater rate, with new treatment approaches showing real promise. The last 15 years since the ISSCR’s founding have laid a strong foundation for future years of exploration, discovery, and advances in medicine. Great science and discovery is always at the center of what we do, and our meetings are a focal point for stem cell science worldwide. This year the ISSCR holds its 15th Annual Meeting June 14–17, 2017, in Boston, bringing together a rich purchase SIRT1/2 Inhibitor IV of researchers from different backgrounds and subject matter areas, to meet with one another, find new collaborations, adopt new approaches, and share excitement, opportunities, and concerns. A new job match program is also offered at the meeting to help connect job seekers with academic institutes, non-profit organizations, and companies looking to fill positions. We hope this will be a valuable service for trainees and others looking to transition in their careers. With its June 2017 issue, Stem Cell Reports enters its fifth year and also shows evidence of both the advancements in the field and the flourishing of the journal itself. The journal continues to exceed our expectations, settling firmly in the ranks of the top journals publishing cutting edge stem cell research and translation. This issue highlights progress across the breadth of stem cell research and its applications to medicine, from mechanistic insights gained through the study of model organisms to pre-clinical analysis of a beta cell replacement transplant approach. In the area of neuroscience, which is close to my heart, I am excited to call out a group of seven papers from Hsieh, Douvaras, Cho, Cowley, Okano, Gage, Schaffer, and colleagues (Brulet et al., 2017; Douvaras et al., 2017; Kim et al., 2017; Haenseler et al., 2017; Yasui et al., 2017; Santos et al., 2017; Rodrigues et al., 2017), reporting the derivation of glial cell types by direct reprogramming or differentiation from pluripotency. These articles describe resources and insights valuable in understanding and finding new approaches to treat multiple pathologies of the central nervous system. We are also delighted to present in this issue Perspectives from ISSCR award winners Qi-Long Ying and Austin Smith (2016 McEwen Award for Innovation; Ying and Smith, 2017) and Leonard Zon (2016 Tobias Award Lecture; Choudhuri et al., 2017) describing the “art of capturing pluripotency” and using the zebrafish to study the regulation of hematopoietic stem cell self-renewal and migration, respectively. The ISSCR is addressing these issues on a variety of fronts as we continue to support our members and the field in advancing stem cell science. Principles that we enumerated in the “2016 Guidelines for Stem Cell Research and Clinical and Translation” (ISSCR, 2016; Daley et al., 2016) are increasingly important, and we rely on them as we advocate for the integrity of the biomedical research enterprise, including review and oversight, replication, and accountability at each stage of research; rigorous pre-clinical data, clinical trials, and patient welfare; and transparency in our communications of progress and results. In 2017, the guidelines were translated into Chinese and Turkish (publication pending) by scientists in those countries who want to ensure that their colleagues, regulators, and other stakeholders in the field have easy access to these important guidelines. The principles and recommendations in the guidelines are central to our policy and communications efforts, providing key messages that underlie outreach to the media, policy makers, and regulatory bodies. These efforts help ensure that the ISSCR is part of critical debates about stem cell research, how it is governed and regulated, and how those issues are presented in the press and to the public. The society’s informational website “A Closer Look at Stem Cells” (http://www.closerlookatstemcells.org/) continues to provide a valuable resource for those interested in knowing more about the science and for would-be consumers to learn more about what is known—and unknown—about stem cell therapies.