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Moreover our present work suggests that AXL could be a
2023-01-19
Moreover, our present work suggests that AXL could be a modulator of sunitinib response, at least for cell lines that present high endogenous levels of this RTK activation, since we observed an increased responsiveness to sunitinib in Z-DEVD-AFC receptor activated with AXL receptor ligand. A role fo
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br Introducing toll like receptors TLRs
2023-01-18
Introducing toll like receptors TLRs are the most important receptors which are expressed on the cytoplasmic and internal vesicles membrane. They have a similar structure including a leucine-rich repeats (LRRs) domain which is out of L-Mimosine membrane, a hydrophobic transmembrane and a toll/in
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Calcineurin has been established to be
2023-01-18
Calcineurin has been established to be a ubiquitous Ca2+-activated serine phosphatase in the nervous system (Pyrzynska et al., 2001). It has been reported that the activation of calcineurin protects aromatase from autophagy-mediated protein degradation, implying that calcineurin-dependent dephosphor
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This progressive behaviour is summarized in Fig which
2023-01-16
This progressive behaviour is summarized in Fig. 4, which depicts the variation in convexity of the obtained cut-off patterns for the series of six antioxidants. The form and degree of convexity of the obtained cut-off curves should in principle correlate with the AOs hydrophobicities, and therefor
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Elevated aminopeptidase activities were often
2023-01-16
Elevated aminopeptidase activities were often detected in organs of plant with accelerated protein turnover, such as leaves and petals during senescence, fruits maturation or in germinating seeds [22]. Moreover, it was proven that these enzymes take part in defense responses [[23], [24], [25]]. Part
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Glu Gln Asp and Asn the
2023-01-16
Glu, Gln, Asp, and Asn, the main never presented in the present study, are involved in nitrogen assimilation and transport processes within the plants. Furthermore, they are used to build up reserves during periods of nitrogen availability for subsequent use in growth, defense, and reproductive pro
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Tephrosia purpurea Linn pers Fabaceae a widely growing herba
2023-01-16
Tephrosia purpurea (Linn.) pers, (Fabaceae), a widely growing herbaceous perennial is reported to exhibit significant anti-hyperglycemic activity in animal models [7], [8], [9] as well as able to delay the development of diabetic complications [10], [11]. Recently, we have reported T. purpurea for i
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br Disclosures br Author contributions br Grants This work w
2023-01-16
Disclosures Author contributions Grants This work was supported by National Institutes of Health/National Heart, Lung, and Blood Institute MERIT Award R37 HL040696 to J.A.F. Acknowledgments Introduction The AGC kinases, named after the protein A, G and C kinases, are an evolutionaril
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The study by Lo http
2023-01-16
The study by Lowry et al. (2001) pointed toward functionally uncharacterized DA- and 5-HT-accumulating neurons within the DMH as a potential target for rapid nongenomic effects of CORT. Similar DA- and 5-HT-accumulating systems are distributed throughout the central and peripheral nervous systems, s
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Moreover an increase of extracellular calcium
2023-01-16
Moreover, an increase of extracellular calcium stimulates BMP-2 expression of pulp Cathepsin S inhibitor synthesis via L-type calcium channel and ERK signaling, which can be attenuated by PD98059 and nifedipine . Dental pulp cells expressed little calcium-sensing receptors . immunohistochemistry s
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br Disclosure br Acknowledgement br Introduction CYP
2023-01-16
Disclosure Acknowledgement Introduction CYP17A1 is a multifunctional enzyme with both 17α-hydroxylase and 17,20-lyase activities and is essential for the biosynthesis of steroidal NB-598 in male testes and adrenal glands. The 17α-hydroxylase activity of CYP17A1 is involved in the conversio
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Among the AXL positive tumors that we
2023-01-16
Among the AXL-positive tumors that we screened, the TNBC cell line MDA-MB-231 showed the highest AXL expression level. Additionally, AXL protein levels were higher in TNBC patient samples than in other breast cancers. Considering the difficulty of, and the urgent need for, effective treatments of TN
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Our outcrossing data confirmed that ACL
2023-01-16
Our outcrossing data confirmed that ACL1 and ACL2 have important temporal and spatial functions in ascospore delimitation in G. zeae. When each ACL deletion mutant was used as male for outcrossing, nuclear division and spore delimitation were not properly progressed in most asci. Ascospores that con
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Autocrine regulations of several adipokines e g leptin and
2023-01-16
Autocrine regulations of several adipokines (e.g., leptin and resistin) on adipocytes have been reported (Karastergiou and Mohamed-Ali, 2010, Ye et al., 2010). Several lines of evidence have shown that apelin influences adipocyte functions, such as, lipolysis and glucose uptake (Dray et al., 2008, Y
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br Guava tea leaves inhibit leukocyte type lipoxygenase
2023-01-14
Guava tea leaves inhibit leukocyte-type 12-lipoxygenase activity Guava tea that is extracted from guava leaves contains a number of polyphenols, and is commonly taken as a dietary supplement. The extracts show a variety of beneficial effects such as antioxidative, anti-inflammatory and antiprolif
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