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br Results br Discussion The present
2022-03-31
Results Discussion The present findings outline a novel regulatory mechanism for fasting-induced ketogenesis, which involves histamine release from mast 4-DAMP into the hepatic portal system, H1 receptor-mediated stimulation of liver OEA biosynthesis, and recruitment of the nuclear receptor P
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Myocardial growth and maturation is regulated in part
2022-03-31
Myocardial growth and maturation is regulated in part by signals from the underlying endocardium (Brutsaert, 2003, de la Pompa and Epstein, 2012, Rentschler et al., 2010). More generally, endothelial raf kinase play an increasingly appreciated role in instructing organogenesis by providing inductiv
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br Materials and methods br
2022-03-31
Materials and methods Results We examined the cardiac mitochondrial density of HKI and markers of oxidative and metabolic stress in trout exposed to an aerated control exposure, an aerated (normoxic) thermal insult, or a hyperoxic thermal insult. Should mtHK provide a cardioprotective effect i
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br Direct effect of HDACs on contractile function by deacety
2022-03-31
Direct effect of HDACs on contractile function by deacetylating cytoskeletal and contractile proteins Role of HDACs in electropathology by transcriptional reprogramming Next to deacetylation of α-tubulin by HDAC6 in experimental and human AF, there is also evidence for transcriptional reprogra
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The endocytic inhibitors MDC and CPZ and dynamin
2022-03-31
The endocytic inhibitors MDC and CPZ and dynamin GTPase blocker (dynamin mutant) have been shown to significantly decrease the intracellular accumulation of cGMP. Moreover, earlier reports suggested that G-protein-coupled receptor (GPCRs) continue to signal by generating cAMP throughout internalizat
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Whereas binding of activated RhoA
2022-03-31
Whereas binding of activated RhoA to the PH domains of the RhoGEFs is proposed to mediate positive feedback regulation (Chen et al., 2010b, Medina et al., 2013), the sequestration of p190RhoGEF by activated Rac1 reveals a novel putative physiological role, that is to utilize Rac1 to directly drive r
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The fact that GSK recognition of
2022-03-31
The fact that GSK-3 recognition of its substrate involves pre-phosphorylation supports the rational for using synthetic phosphorylated peptides as substrate competitive inhibitors [57]. Phosphorylated peptides derived from the N-terminal pseudosubstrate sequence of GSK-3β were very weak inhibitors o
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Introduction Multiple sclerosis MS a neurological autoimmune
2022-03-31
Introduction Multiple sclerosis (MS), a neurological autoimmune disease, is driven by CD4+ L-365,260 of the T helper (TH) cells [1]. There is no curative treatment for MS and the present treatments typically focus on immunomodulation for slowing the progression of the disease. These includes inter
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A few methods have been developed to separate and
2022-03-31
A few methods have been developed to separate and prepare compounds from L. chinensis, such as silica gel column chromatography [5,6] and high-performance liquid chromatography (HPLC) [7]. Silica gel column chromatography is still used for its simple equipment and low cost. However, this method is o
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The GPR gene was included in our survey because
2022-03-31
The GPR35 gene was included in our survey because of its location immediately 3′ to CAPN10 and because it showed evidence of association with type 2 diabetes. Also, its expression in tissues including pancreatic islets and skeletal muscle is consistent with a possible role in type 2 diabetes. Our re
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Cichlasoma dimerus as most teleost fish species present neur
2022-03-31
Cichlasoma dimerus, as most teleost fish species, present neurons expressing GnRH3 (Pandolfi et al., 2005). As in most aldehyde dehydrogenase inhibitor species, the neurons expressing GnRH3 are mainly located in the NOR, although few neurons were detected in the olfactory bulb, ventral telencephalon
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We first investigated the influence of the acyl group of
2022-03-31
We first investigated the influence of the -acyl group of the glycine amide side chain and found that shorter linkers lead to better activities (–); simple -benzoyl substituents were always superior to the 3-arylpropanoyl group present in the high-throughput hit (). Electron withdrawing substituents
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PFI 3 Heparin and suramin are highly negatively charged mole
2022-03-31
Heparin and suramin are highly negatively charged molecules, and they are in this aspect, similar to DNA and likely to compete with DNA by binding to the protein cationic groups [17] (Fig. 1). The inhibitory effect of heparin and suramin on DNA and RNA binding proteins has been described [[18], [19]
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An increased sympathetic tone and the hormone glucagon are
2022-03-31
An increased sympathetic tone and the hormone glucagon are the main glucose mobilizing factors [28], [29]. Single-cell transcriptome analysis of human islet cells suggests the expression of Ffar1 not only in β-cells but also in α-cells [30]. Moreover, analysis of rat α-cells indicates that FFAR1 exp
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Studies examining cerebral glucose metabolism in
2022-03-31
Studies examining cerebral glucose metabolism in MDD using 18 F-fluorodeoxyglucose in positron emission tomography (FDG-PET) showed altered regional glucose metabolism in MDD (Dunn et al., 2002, Kennedy et al., 2001, Kimbrell et al., 2002, Saxena et al., 2001). In a recent meta-analysis by Su and co
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