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br Acknowledgments The authors would like to
2021-11-22
Acknowledgments The authors would like to thank principal investigator Edward John Pratt, MD (Lilly-NUS Centre for Clinical Pharmacology, Singapore) and study investigator Martha Hernandez-Illas MD (QPS-MRA) along with site staff, and trial participants and their families. We thank Zvonko Milicev
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br Materials and methods br
2021-11-22
Materials and methods Conflicts of interest Some of the peptidomimetic compounds in this work are the subject of the patent application “Peptidomimetics for Imaging the Ghrelin Receptor”, WO/2016/191865 A1, December 8th, 2016. Acknowledgements Special thanks go to Rebecca McGirr (Lawson He
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The overall decrease in consummatory drive seen in
2021-11-22
The overall decrease in consummatory drive seen in rodents treated with naltrexone in previous studies is in accordance with the effects seen with mice treated with SNAP 37889 in this study. While it may seem inappropriate to use a broad-acting drug like SNAP 37889 that suppresses overall consummato
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Here we show in contrast
2021-11-20
Here we show, in contrast to previous work, that several phenotypes associated with Orb6 inactivation, including increased cell width, are independent of Gef1. We further find that Orb6 positively regulates exocytosis, also independently of Gef1. To identify novel targets of Orb6, we performed quant
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Several recent studies have linked clock function
2021-11-20
Several recent studies have linked clock function with the cell cycle and reported that clock components, such as PER1, PER2, BMAL1, and CRY1/2 decrease cell proliferation or improve the action of anti-cancer drugs in different cancer cell lines. Moreover, certain types of human cancer show an alter
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Biological evaluations of the compounds
2021-11-20
Biological evaluations of the compounds were done both using HCV protease and replicon assays. Results are shown in . The protease inhibitory IC’s were determined using a FRET assay with HCV NS3/4A 1a protease domain. The replicon EC’s were determined using a replicon luciferase cell-based assay. Th
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The opposite modulation observed for circulating LPI levels
2021-11-20
The opposite modulation observed for circulating LPI levels and WAT GPR55 luciferin definition by nutritional status suggests that increased levels of LPI may down-regulate the expression of its receptor in WAT, whereas in conditions of low serum LPI levels, the expression of GPR55 is stimulated. H
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Initial evidence that cell contact
2021-11-20
Initial evidence that cell-contact-mediated transmission of HIV-1 is relevant for the generation of latently infected TBCA was suggested in the context of transmission from dendritic cells to resting CD4+ T cells (Evans et al., 2013, Kumar et al., 2015). As dendritic cells probe for antigens, they
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protease inhibitor cocktail br Endogenous lipids as SLC tran
2021-11-20
Endogenous lipids as SLC6 transporter modulators Lipids constitute part of the environment in which membrane-embedded transporters operate [62]. Endogenous lipids can act as inhibitory ligands [63] or functionally important components of the membrane that impart changes in transporter structure [
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br Investigations br Genetics GLUT is a
2021-11-20
Investigations Genetics GLUT1 is a membrane-bound glycoprotein that provides base-rate glucose transport across blood-tissue barriers. It is constituitively expressed in erythrocytes, MAPK Inhibitor Library microvessels and astroglia. The gene exclusively associated with GLUT1 is SLC2A1, loca
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br Results br Discussion Arc p forms
2021-11-20
Results Discussion Arc1p forms a ternary complex with ScMetRS and ScGluRS and acts as a tIF in trans of both synthetases to improve their catalytic efficiencies.20., 24. The human homolog of Arc1p, the p43 protein, is associated within a multi-enzyme complex containing nine aminoacyl-tRNA synt
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Sodium ascorbate The identification of distinct expression d
2021-11-19
The identification of distinct expression domains in the limb suggested that these domains might have specific biological functions. We explored this possibility by determining enriched biological processes for each category using GO ontology term analysis (WebGestalt) (Zhang et al., 2005). Category
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The H R antagonist cimetidine Tagamet became the
2021-11-19
The H2R antagonist cimetidine (Tagamet™) became the first billion-dollar drug in the 1980s for the treatment of peptic ulcer disease. Other H2R antagonists include ranitidine, famotidine, nizatidine, and zolantidine, the latter showing good BBB penetration with a steady-state brain/blood ratio of 1.
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HBV is an enveloped double stranded DNA virus which
2021-11-19
HBV is an enveloped, double-stranded DNA virus, which is transcripted into four major transcripts [6]. Among them, the 3.5 kb pregenomic RNA (pgRNA) directs the translation of HBV polymerase, core protein and acts as template for reverse transcription. So viral transcription is a key step of virus l
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GPR has been implicated in neuropathic and inflammatory pain
2021-11-19
GPR55 has been implicated in neuropathic and inflammatory pain (Staton et al., 2008) and bone remodeling (Whyte et al., 2009). Thus delineating the pharmacology of this receptor and the discovery of selective agonists and antagonists merits further study and could lead to new therapeutics. Acknow
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