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br Conclusion The following is the supplementary data
2021-09-08
Conclusion The following is the supplementary data related to this article. Conflict of interest Funding Acknowledgements Peroxiredoxin VI (Prdx6) is a dual-functioning antioxidant enzyme that acts to protect biological membranes against damage caused by lipid peroxidation , . The enz
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Furthermore a direct thiol protective role of S
2021-09-08
Furthermore, a direct thiol protective role of S-nitrosylation has been reported in animals [66]. Here, formation of higher order irreversible oxidative modifications, such as sulfinic and sulfonic acids were prevented by S-nitrosylation. All these observations underline the important role of ROS in
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In our study we evaluated adenovirus
2021-09-08
In our study we evaluated adenovirus type 5 (Ad5) as a vehicle for delivering Cre recombinase in conditional transgenic mouse based on the Cre-loxP system, in order to achieve GlyT1 gene modulation in a specific thalamic region in the adult animal. GlyT1 is a sodium- and chloride-coupled glycine tra
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br Conclusion br Conflict of interest statement br Acknowled
2021-09-08
Conclusion Conflict of interest statement Acknowledgements This work was supported by the National Science Foundation (MCB-1817417 to S.D.) and National Institutes of Health (R01-GM72711 to A.C.D.). We thank members of the Delaney laboratory for careful reading of the manuscript and helpful
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However the GPR R H polymorphism was reported to affect
2021-09-08
However, the GPR40 R211H polymorphism was reported to affect the variation of insulin secretory capacity in other ethnic groups. The allele frequency of H211 in Japanese was 78.4%.102, 103 By comparing clinical and metabolic parameters among Japanese men, Ogawa et al. found that histidine homozygote
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br Materials and methods br Results br Discussion
2021-09-08
Materials and methods Results Discussion In nerve terminals, Na+-dependent glutamate transporters of the plasma membrane are responsible for the maintenance of low (non-toxic) extracellular glutamate concentrations and accomplish uptake of glutamate into the SB269970 HCl of neurons and gli
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Our data suggest that Slc a is important for amino
2021-09-08
Our data suggest that Slc38a5 is important for amino-acid-induced α cell proliferation and expansion of α cell mass following GCGR inhibition, but not for formation and maintenance of α cell mass. This is supported by the finding that Slc38a5−/− mice have normal α cell mass. This is interesting sinc
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Receptors for glucagon Gcgr GLP Glp r and GLP Glp
2021-09-08
Receptors for glucagon (Gcgr), GLP-1 (Glp1r), and GLP-2 (Glp2r) are G-protein coupled receptors (GPCRs) belonging to class B-1 (secretin receptor-like) family of GPCRs (Harmar, 2001, Fredriksson et al., 2003). The mammalian Gcgr, Glp1r, and Glp2r genes, together with the px12 for the receptors for
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The novel Ghsr IRES Cre knock in
2021-09-08
The novel Ghsr-IRES-Cre knock-in mouse line allowed us to deconstruct the involvement of MBH GHSR-expressing neurons in mediating food intake responses using chemogenetic modulation of their neuronal activity. In our studies, hM4Di DREADD virus injections to inhibit GHSR neurons targeted several nuc
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The SNPs of candidate genes may exert their effect
2021-09-08
The SNPs of candidate genes may exert their effect on associated traits through changing of gene expression (Bonafe et al., 2003, Wyszynska-Koko et al., 2006). In agreement, GHSR SNPs were significantly associated with upregulation of this gene in the pituitary gland of GG/GG chickens. The GHRL/GHSR
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Phos-tag Acrylamide br Materials and methods br
2021-09-08
Materials and methods Results Discussion BTB, as a necessary structure for the spermatogenic epithelium, provides an important internal environmental for spermatogenesis and its disruption leads to male infertility (Qiu et al., 2016). GJs and TJs which are mainly components of BTB play esse
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br Pannexins which form channels connecting cells with
2021-09-08
Pannexins, which form channels connecting Pimasertib australia with the extracellular environment, have also been studied in the setting of NASH. When open these channels participate in inflammatory processes. A decrease in lobular inflammation and oxidative stress was observed in mice with panne
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NMDARs are glutamate gated ionotropic receptors that
2021-09-08
NMDARs are glutamate-gated ionotropic receptors that are involved in excitatory neurotransmission and plasticity (Traynelis et al., 2010). There have been several reports showing that neurosteroids acting as negative modulators of NMDARs exert neuroprotective activity in both in vitro and in vivo mo
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An advantage of photolabeling with tritiated photoprobes fol
2021-09-08
An advantage of photolabeling with tritiated photoprobes followed by microsequencing with Edman degradation is the ability to both identify the photolabeled 2-Chlorotrityl Chloride Resin mg and to quantify photoincorporation which enables assessment of pharmacological specificity and allosteric int
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Activation of FXR or TGR inhibits inflammatory response via
2021-09-08
Activation of FXR or TGR5 inhibits inflammatory response via repressing NF-κB activity [1]. FXR is not expressed or expressed at a very low level in macrophages [45] (data not shown), but highly expressed in hepatocytes. In contrast, TGR5 is expressed in macrophages but not in hepatocytes. Our data
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