• br Acknowledgements br Introduction Autoantibodies directed

  2024-11-06

  

  Acknowledgements Introduction Autoantibodies directed at neurotransmitter receptors and ion channels are pathogenic and/or biomarkers in several autoimmune neurological diseases [1]. For example, autoantibodies directed against voltage-gated potassium channels, the P/Q-type (α1A) voltage-gated

• Introduction Myasthenia gravis MG is an autoimmune disorder

  2024-11-06

  

  Introduction Myasthenia gravis (MG) is an autoimmune disorder characterized by muscle weakness, which is mainly due to autoantibodies reducing the number or function of postsynaptic n-acetyl-l-cysteine receptors (AChRs) [1], [2]. Animal models have been developed to uncover the immunopathogenesis o

• Casein accounts for of the total protein

  2024-11-06

  

  Casein accounts for 80% of the total protein in bovine milk (Capriotti, Cavaliere, Piovesana, Samperi, & Laganà, 2016); hydrolysates or bioactive peptides derived from casein have been employed widely in food as a functional ingredient (Capriotti et al., 2016, Field et al., 2008). Many studies have

• br Acknowledgments br Introduction Hypospadias

  2024-11-06

  

  Acknowledgments Introduction Hypospadias is a common congenital malformation in males, in which the urethral orifice is found on the ventral side of the penis as a result of incomplete fusion of urethral folds. The mean prevalence in per 10,000 live births from 1910 to 2013 were: Europe 19.9,

• br Introduction Nausea and vomiting are among the most

  2024-11-06

  

  Introduction Nausea and vomiting are among the most distressing side effects associated with chemotherapy in cancer patients (Billio et al., 2010). Severe emesis can negatively affect a patient's nutritional state, ability to work and motivation, which can, in turn, interfere with the clinical co

• For the NSCLC patients with EGFR activating mutations

  2024-11-06

  

  For the NSCLC patients with EGFR-activating mutations, EGFR-TKIs (gefitinib and erlotinib) are effective clinical therapies [21], [22]. However, approximately 10% of patients harboring EGFR-sensitizing mutations exhibit intrinsic resistance, and up to 40% do not attain a major response to treatment

• hdac inhibitors Pompe disease is accompanied by the deficien

  2024-11-06

  

  Pompe disease is accompanied by the deficiency of the lysosomal α-1,4-glucosidase that makes the hdac inhibitors unable to hydrolyze glycogen to glucose, thereby resulting in the accumulation of glycogen in lysosomes, especially in skeletal muscles and cardiac tissues. This accumulation results in

• Several approved and or experimental drugs together

  2024-11-06

  

  Several approved and/or experimental drugs, together with natural compounds, have been reported to induce autophagy in different cancer types [70], [71], [72] (Table 1). In the next paragraphs, we will review more in detail a group of these agents selected in relation to their promising future outco

• In recent years the higher

  2024-11-06

  

  In recent years, the ‘higher lipophilicity’-thus-‘better performance’ tenet, derived from the polar paradox theory applied to micro-structured media, was challenged by novel and unexpected experimental results. In particular, the synthesis of many complete series of fatty dapagliflozin esters of na

• br Removal of therapeutic doses of antibiotics from Marek s

  2024-11-06

  

  Removal of therapeutic doses of mCAP synthesis from Marek’s Disease Vaccines The impact of this change seems to vary widely among operations, probably dependent on the pre-existing quality of hatching egg production, hatchery sanitation, hatchery management, and brooding management. Increases in

• Natural compounds present in medicinal and or nutritional

  2024-11-06

  

  Natural compounds, present in medicinal and/or nutritional plants as well as in macrofungi sources, have stimulated a great interest from the pharmaceutical industry. Different natural compounds such as phenolic compounds, alkaloids, terpenoids among others, have shown strong antiangiogenic effects

• Electron paramagnetic resonance studies of mixtures of A and

  2024-11-05

  

  Electron paramagnetic resonance studies of mixtures of Aβ1–40 and Aβ1–42 suggest that interlaced fibrils might also form [40] where Aβ1–40 and Aβ1–42 is found within the same fibril. Considering the Aβ fold rather than the sequence, these observations imply two mechanisms that might lower the total

• Immunohistochemistry Hearts from young and aged mice

  2024-11-05

  

  Immunohistochemistry: Hearts from young and aged mice were collected at the indicated times, fixed overnight in 10% formalin, and embedded in paraffin. Serial 5-μm heart sections from each group were analyzed. Samples were stained with H&E for routine histologic examination. Immunohistochemical stai

• Mast cells Mast cells are immune

  2024-11-05

  

  Mast cells. Mast histone deacetylase inhibitors are immune cells of the myeloid lineage and are ubiquitously present in connective tissues [75]. These cells are involved in the modulation of a number of physiological functions, such as vasodilation, angiogenesis, bacterial, and parasite elimination

• br Actin at presynapses br Conclusion Thanks to

  2024-11-05

  

  Actin at presynapses Conclusion Thanks to the recent discovery of rings, hotspots and trails, axonal OSMI-1 is back in the spotlight. These are exiting times for neuronal cell biologists armed with constantly improving labeling and imaging techniques to observe, quantify and perturb these str

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