• Previously we demonstrated that injured kidney tissues can i

  2018-11-08

  

  Previously, we demonstrated that injured kidney tissues can induce bone marrow stromal buy NSC74859 to differentiate into renal tubular epithelial-like cells in vitro and in vivo (Qian et al., 2008). However, another work reported that the beneficial effects of BMSCs are primarily mediated by compl

• The functional roles of SOX in human pluripotency maintenanc

  2018-11-08

  

  The functional roles of SOX2 in human pluripotency maintenance and lineage differentiation were recently reported (Wang et al., 2012). SOX2 is not essential for hESC self-renewal. However, overexpression of SOX2 results in the promotion of neural ectodermal differentiation and the suppression of def

• In this study we used dermal fibroblasts

  2018-11-08

  

  In this study we used dermal fibroblasts derived from three different patients with distinct mutations in the TAZ1 gene (Houtkooper et al., 2009) and generated BTHS patient-specific iPSCs. We fully characterized them in terms of pluripotency both in vitro and in vivo. Similar to human ESCs, all gene

• br Introduction Pancreatic ductal adenocarcinoma remains one

  2018-11-08

  

  Introduction Pancreatic ductal adenocarcinoma remains one of the most aggressive and devastating tumor malignancies with an overall 5-year survival rate of less than 5% (Kern et al., 2011). The only potentially curative treatment is the complete surgical resection of the tumor. Nevertheless, even

• caspofungin To identify the label retaining cells

  2018-11-08

  

  To identify the label-retaining caspofungin within the myocardium, BrdU was administrated and the intensity of the BrdU signal was examined after a prolonged chasing period (Urbanek et al., 2006). As expected, the number of bright BrdU-CSCs in the atria decreased rapidly after chasing while the num

• Over the last decade a number

  2018-11-08

  

  Over the last decade, a number of studies have proposed that the adult mammalian heart is not a terminally differentiated organ and is capable of turning over cardiomyocytes throughout life and following injury (Porrello and Olson, 2010). The most compelling evidence for this radical concept comes f

• Phos-tag Biotin BTL-105 Recent research suggests that NSCs t

  2018-11-08

  

  Recent research suggests that NSCs\' tropism towards neoplastic areas is driven by chemoattractants produced at the tumor site. The intratumoral hypoxic microenvironment activates SDF-1/CXCR4 and VEGF/VEGFR signaling pathways, which may act as downstream effectors to increase NSC tropism (Aboody et

• BSS PBMC iPS F expressed the endogenous pluripotent transcri

  2018-11-08

  

  BSS1-PBMC-iPS4F4 expressed the endogenous pluripotent transcription factors OCT3/4, SOX2, REX1 and NANOG, assessed by RT-PCR (Fig. 2A) and the protein pluripotent markers SSEA3, SSEA4, Tra1–60, Tra1–81 and Oct3/4, evaluated by flow cytometry analysis (Fig. 2B). To demonstrate the capacity of BSS1-PB

• The chronotropic responses of the hPSC CMs to various

  2018-11-08

  

  The chronotropic responses of the hPSC-CMs to various cardio-active drugs in our study are well in line with the published results (Mandel et al., 2012; Pillekamp et al., 2009; Pillekamp et al., 2012; Xu et al., 2002), in which the beating rates of CMs were increased in response to isoproterenol and

• Many authors suggest that an increased production of ROS in

  2018-11-08

  

  Many authors suggest that an increased production of ROS in the beginning of differentiation is an essential factor for adipogenesis (Liu et al., 2012; Zhou et al., 2014; Wang and Hai, 2015). ROS could, in small quantities, act in cell signaling (Mc Bride et al., 2006; Zhang and Gutterman, 2007) and

• br Materials and methods br Acknowledgments We

  2018-11-08

  

  Materials and methods Acknowledgments We would like to thank Dr. Keisuke Okita and Prof. Shinya Yamanaka for providing the oleuropein for reprogramming. We thank I Bente Smith Thorup for excellent technical assistance in the cell culture. We thank Jeannette Schoene and Dirk A. Pflumm for cyto

• The NAD dependent protein silent information regulator Sir i

  2018-11-08

  

  The NAD-dependent protein silent information regulator 2 (Sir2) is a deacetylase for histones and other proteins and a key regulator of life span in several organisms. Sirtuin (SIRT)1 of the Sirtuin family is the closest homolog of yeast Sir2 in mammals and has critical functions in the regulation o

• In our static wells the average aggregate diameter was m

  2018-11-08

  

  In our static 12 wells, the average aggregate diameter was ∼210 μm, representing a relatively large spread of ∼100–400 μm in each well, typical of random aggregation. However, at 7.5 μM CHIR, cftr of all shapes and sizes differentiated into contracting, GFP+ EBs, whereas, at suboptimal CHIR concentr

• Our goal was to generate a viable homozygous

  2018-11-08

  

  Our goal was to generate a viable homozygous strain that would engraft with high efficiency without irradiation. Based on previously reported Kit mutant phenotypes (Geissler et al., 1981), we hypothesized that the Kit could be maintained as a homozygous line when crossed with the NSG, and the contri

• It has furthermore been speculated whether Sca plays a role

  2018-11-08

  

  It has furthermore been speculated whether Sca-1 plays a role in stem cell self-renewal. Thus, some experiments with Sca-1 −/− knock-out mice investigating hematopoietic and mesenchymal progenitor mg115 have pointed to a role for Sca-1 in self-renewal (Bonyadi et al., 2003; Ito et al., 2003). Howev

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