• Despite the potential for tissue specific

  2018-10-24

  

  Despite the potential for tissue specific accumulation of dysfunctional mitochondria, MRT understandably is of considerable appeal to couples coping with a devastating mitochondrial disease as such intervention provides the only hope for a healthy child. Depending on the tissues and proportion of di

• br Towards successful transplantation of

  2018-10-24

  

  Towards successful transplantation of human ITT Where there is no risk of neoplastic contamination of the tissue that could lead to retransmission of cancer thrombin inhibitors back to the cured patient, autotransplantation of testicular tissue pieces may be considered for fertility restoration.

• Our objective was to determine how the

  2018-10-24

  

  Our objective was to determine how the culturing of CD34+ nicotinic receptors under conditions that influence ARNT complex formation might affect the expansion of HSPCs. We hypothesized that the use of culture conditions that stabilize HIF-1α and antagonize the AhR protein would promote the expansi

• br Author contributions br Resource table Resource details

  2018-10-24

  

  Author contributions Resource table. Resource details Previously we have generated an induced pluripotent stem cell line (named MHHi002-A) from a male CF patient homozygous for the mutation p.Phe508del in the CFTR gene. Thereby the absence of the three bases CTT results in the deletion of phe

• Here we present an algorithm KeyGenes

  2018-10-24

  

  Here we present an algorithm, KeyGenes, that we have used on NGS data extracted from tissues of 21 different human fetal organs, both embryonic and extraembryonic (plus the maternal endometrium), from the first and second trimesters of development to determine a panel of classifier genes that would

• Here we study the impact of the common

  2018-10-24

  

  Here we study the impact of the common GBA-N370S mutation on the phenotype of patient-specific dopaminergic neuronal cultures differentiated from iPSC lines derived from patients with PD and identify deficits in protein homeostasis. Our results suggest that the heterozygous GBA-N370S mutation leads

• These data are in agreement with prior studies

  2018-10-24

  

  These data are in agreement with prior studies demonstrating that hyaluronan levels play a critical role in determining the site of HSC lodgment/engraftment following transplantation (Avigdor et al., 2004; Ellis et al., 2007, 2009, 2011; Nilsson et al., 2003), and that HSC exhibit preferential engra

• glucose assay HSC functions are severely compromised followi

  2018-10-24

  

  HSC functions are severely compromised following acute and chronic TLR4 activation (Esplin et al., 2011; Rodriguez et al., 2009). We demonstrated that TRIF signaling is a critical mediator of HSC injury, since its deletion fully restores HSC functions following LPS exposure. Transplantation of LPS L

• The experimental design of this

  2018-10-24

  

  The experimental design of this model provides several differences to standard 2D culture: EHTs are anchored between two flexible silicone posts, which generate a preload, and EHTs perform auxotonic contractile work (the physiological form of cardiac contraction) against elastic posts. This results

• Induced pluripotent stem cell iPSC technology holds great

  2018-10-24

  

  Induced pluripotent stem cell (iPSC) technology holds great promise for future autologous cellular therapies for vascular diseases (Tavernier et al., 2013). However, a major concern is the availability of approaches to differentiate iPSCs into large quantities of functional VSMCs for research and th

• br Results To investigate the molecular and cellular phenoty

  2018-10-24

  

  Results To investigate the molecular and cellular phenotypes perturbed in DS, we compared DS and normal ESCs and their neural derivatives. In the past, we have isolated three DS-ESC lines, namely CSES13, CSES20, and CSES21, from PGS-derived embryos with trisomy of chromosome 21 (Figure 1A) (Bianc

• br Experimental Procedures br Author Contributions

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments The targeted Ainv15 mESC line with was a kind gift from Paul Gadue (University of Pennsylvania). We would like to thank Brian R. Tilton and Patrick Autissier from the BU Flow Cytometry Core Facility as well as Michael T. Kirber fr

• A complementary study confirms our findings that GATA is nec

  2018-10-24

  

  A complementary study confirms our findings that GATA6 is necessary for s6 kinase specification as well as the decreased efficiency of β-like cell generation from the GATA6 PSC line (Shi et al., 2017). This other report did have one major discrepancy with our results; they did not see a defect in g

• Overall our data support the view

  2018-10-24

  

  Overall, our data support the view that the SEZ is a source of plasticity for the adult CC, and that oligodendroblasts could be a valid therapeutic tool for demyelinating diseases if their generation from wider parts of the SEZ could be stimulated, if their response could be sustained for long perio

• Main Text In so many ways

  2018-10-24

  

  Main Text In so many ways the field is stronger than ever, with terrific progress in stem cell research and discovery that has led to advances in regenerative medicine. We see research moving toward the clinic at a greater rate, with new treatment approaches showing real promise. The last 15 years

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