• The experimental design of this

  2018-10-24

  

  The experimental design of this model provides several differences to standard 2D culture: EHTs are anchored between two flexible silicone posts, which generate a preload, and EHTs perform auxotonic contractile work (the physiological form of cardiac contraction) against elastic posts. This results

• Induced pluripotent stem cell iPSC technology holds great

  2018-10-24

  

  Induced pluripotent stem cell (iPSC) technology holds great promise for future autologous cellular therapies for vascular diseases (Tavernier et al., 2013). However, a major concern is the availability of approaches to differentiate iPSCs into large quantities of functional VSMCs for research and th

• br Results To investigate the molecular and cellular phenoty

  2018-10-24

  

  Results To investigate the molecular and cellular phenotypes perturbed in DS, we compared DS and normal ESCs and their neural derivatives. In the past, we have isolated three DS-ESC lines, namely CSES13, CSES20, and CSES21, from PGS-derived embryos with trisomy of chromosome 21 (Figure 1A) (Bianc

• br Experimental Procedures br Author Contributions

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments The targeted Ainv15 mESC line with was a kind gift from Paul Gadue (University of Pennsylvania). We would like to thank Brian R. Tilton and Patrick Autissier from the BU Flow Cytometry Core Facility as well as Michael T. Kirber fr

• A complementary study confirms our findings that GATA is nec

  2018-10-24

  

  A complementary study confirms our findings that GATA6 is necessary for s6 kinase specification as well as the decreased efficiency of β-like cell generation from the GATA6 PSC line (Shi et al., 2017). This other report did have one major discrepancy with our results; they did not see a defect in g

• Overall our data support the view

  2018-10-24

  

  Overall, our data support the view that the SEZ is a source of plasticity for the adult CC, and that oligodendroblasts could be a valid therapeutic tool for demyelinating diseases if their generation from wider parts of the SEZ could be stimulated, if their response could be sustained for long perio

• Main Text In so many ways

  2018-10-24

  

  Main Text In so many ways the field is stronger than ever, with terrific progress in stem cell research and discovery that has led to advances in regenerative medicine. We see research moving toward the clinic at a greater rate, with new treatment approaches showing real promise. The last 15 years

• There was an attempt to explain the physiological meaning of

  2018-10-24

  

  There was an attempt to explain the physiological meaning of the balance between the oligomeric and the monomeric forms of the sigma-1 receptor by the hypothesis that oligomerization of the sigma-1 receptor regulates its ligand-mediated functions [57]. Presumably, the sigma-1 receptor ligands can in

• The goal of this study is to obtain the information

  2018-10-24

  

  The goal of this study is to obtain the information on the temperature Pepstatin A of the magnetic properties of the LSMO-0.07 and LSMO-0.125 compounds in the 4–240K temperature range, i.e., exactly where the unusual macroscopic properties of these materials are observed. The experimental part

• MG132 Magnetohydrodynamic MHD flow and heat transfer

  2018-10-24

  

  Magnetohydrodynamic (MHD) flow and heat transfer for a fluid has enormous applications in many engineering problems such as MHD power generators, petroleum industries, plasma studies, geothermal MG132 extractions, the boundary layer control in the field of aerodynamics and many other applications [7

• br Introduction Light emitting diodes LEDs due to their tech

  2018-10-24

  

  Introduction Light emitting diodes (LEDs) due to their technical and economic advantages (low power consumption, a long service life and low service costs, a small size, the absence of hazardous IR and UV radiation, ease of disposal) are the leading contenders for future light sources. Currently,

• br Funding This work was supported by the

  2018-10-24

  

  Funding This work was supported by the Swedish Research Council for Health, Working Life and Welfare (FORTE) under Grant number 2014-0445 for Jenny Torssander, and by the University of Copenhagen for Laust H Mortensen. Body Reports of disrespectful maternity care are emerging worldwide, despi

• Contrary to our results transient increases in cardiac speci

  2018-10-23

  

  Contrary to our results, transient increases in cardiac-specific troponin have been observed in 12–50% of patients following trastuzumab treatment, most frequently after the first cycle, and troponin-I was found to be the strongest independent predictor of cardiotoxicity in multivariate analyses (Ca

• The higher mortality in sickle cell disease compared to the

  2018-10-23

  

  The higher mortality in sickle cell disease compared to the general population may be due to heighten inflammatory response in sickle cell disease relative to subjects without sickle cell disease. For example recent advances have shown that specific SCR7 and T cells directly influence a cytokine im

• br Introduction Cystic Fibrosis CF is an autosomal recessive

  2018-10-23

  

  Introduction Cystic Fibrosis (CF) is an autosomal recessively inherited disease most prevalent in Caucasian populations of European origin (World Health Organization, 2004). In the UK about 10,000 people have CF, globally about 70–100,000 people are affected (World Health Organization, 2004). Alt

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