• janus kinase br Resource table Resource details Following th

  2018-10-20

  

  Resource table: Resource details Following their mechanical isolation from day 7 blastocysts, the inner cell masses (ICM) were seeded individually onto the feeder layers. After 2days of incubation, most of the ICMs were found attached to the feeder cells. The cultures were allowed to grow for 8–

• In addition to PES pre treatment increasing HPC adhesion

  2018-10-20

  

  In addition to PES pre-treatment increasing HPC7 adhesion within the colon, it also concomitantly reduced pulmonary presence, thereby reducing non-specific retention in healthy tissues. Pulmonary entrapment is a major obstacle for systemic HSPC delivery for regenerative purposes both experimentally

• In the current study we compared

  2018-10-20

  

  In the current study, we compared two different genetic backgrounds on the induction and maintenance of multipotency by generating clonal iNSC lines from two distinct mouse strains (C57BL/6 vs. C3H). Clonal iNSC lines from distinct genetic backgrounds exhibited the distinct levels of conversion effi

• Induction of EndMT results from integration of

  2018-10-20

  

  Induction of EndMT results from integration of multiple extrinsic inputs within the dynamically shifting cellular environment of cardiogenesis. Owing to the membrane bound presentation of ligands, Notch signaling status is dependent on the organization and distribution of signal-presenting and signa

• The karyotype of the BIOT EHMT iPSC line

  2018-10-20

  

  The karyotype of the BIOT-0708-EHMT1 iPSC line was determined with Giemsa-banding, proving normal diploid 46, XX karyotype, without any detectable abnormalities (Fig. 1B). In parallel, the pathogenic NM_024757.4(EHMT1):c.3413G>A mutation was confirmed by Sanger sequencing in the newly established iP

• Also critical to the success of hard tissue engineering stra

  2018-10-20

  

  Also critical to the success of hard tissue engineering strategies is the selection and use of an appropriate growth factor regimen. Although several growth factors are reported to play an important role in the process of matrix mineralisation, IGF-1 is the most abundant growth factor in bone matrix

• Previously we showed that the

  2018-10-20

  

  Previously, we showed that the transcription factor SLUG is an important regulator of mammary epithelial lineage commitment and differentiation (Proia et al., 2011). Recent studies have also shown that SLUG is necessary for the mammary stem cell state (Guo et al., 2012). However, SLUG-deficient mice

• Another remarkable observation of this study is that

  2018-10-20

  

  Another remarkable observation of this study is that ASCL1-iN calcifediol are exclusively excitatory. This is surprising, because ASCL1 is not typically associated with the excitatory neuronal lineage during neural development (Bertrand et al., 2002; Fode et al., 2000; Guillemot et al., 1993; Johns

• Traditionally the effects of radiation on

  2018-10-20

  

  Traditionally, the effects of radiation on spermatogonia have been evaluated by morphological analyses. It is considered that the percentage of seminiferous tubule cross-sections that show type A spermatogonia 10 days after irradiation is representative of SSC survival (van der Meer et al., 1992). A

• To test whether transgenic Cre mouse lines are

  2018-10-20

  

  To test whether transgenic Cre mouse lines are capable of specific targeting APCs in vivo, mice carrying the Cre recombinase-responsive Enhanced Yellow Fluorescent Protein (EYFP) allele in the Rosa locus (Rosa-EYFP) (Srinivas et al., 2001) were crossed to one of three Cre lines. These lines were cho

• Direct cell reprogramming technology is

  2018-10-20

  

  Direct cell-reprogramming technology is based on the dominant action of cell-lineage transcription factors (TFs) in converting adult somatic cells into different cell types (Graf and Enver, 2009). This technique represents a promising avenue in the field of regenerative medicine, with the potential

• Existing treatments for myelomeningocele repair consist

  2018-10-20

  

  Existing treatments for myelomeningocele repair consist of pre- or post-natal surgical closure of the defect. Prenatal intervention has been shown to be more effective than postnatal surgery because it can prevent or ameliorate sequels (Adzick et al., 2011; Adzick et al., 1998; Meuli et al., 1997; M

• To reprogram patient cells we adopted the most feasible and

  2018-10-20

  

  To reprogram patient cells, we adopted the most feasible and safest protocol using a patient cell source that is easy to obtain, PB-MNCs, and an integration-free reprogramming strategy based on SeV vectors. PB-MNCs were chosen, as blood collection is common in patient follow-up and is minimally inva

• Recently we found that vesicular monoamine transporter VMAT

  2018-10-20

  

  Recently, we found that vesicular monoamine transporter 2 (VMAT2) regulates monoamine (including dopamine) storage by acting as a negative regulator, such that high monoamine levels inhibit the progression from Pdx1+ pancreatic progenitor Nanaomycin A to Neurog3+ endocrine progenitor cells of ESC-de

• order GDC-0879 Our study made use of single cell transcripti

  2018-10-20

  

  Our study made use of single-cell transcriptional profiling to define the heterogeneity of hormone-producing order GDC-0879 derived from hPSCs. The technology is a powerful tool that allowed us to determine the percentage of various hormone-producing cells and shifts in this distribution upon treatm

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