• The higher mortality in sickle cell disease compared to the

  2018-10-23

  

  The higher mortality in sickle cell disease compared to the general population may be due to heighten inflammatory response in sickle cell disease relative to subjects without sickle cell disease. For example recent advances have shown that specific SCR7 and T cells directly influence a cytokine im

• br Introduction Cystic Fibrosis CF is an autosomal recessive

  2018-10-23

  

  Introduction Cystic Fibrosis (CF) is an autosomal recessively inherited disease most prevalent in Caucasian populations of European origin (World Health Organization, 2004). In the UK about 10,000 people have CF, globally about 70–100,000 people are affected (World Health Organization, 2004). Alt

• The diverse complex molecular events

  2018-10-23

  

  The diverse, complex molecular events involved in the initiation and development of malignant neoplasm require functional changes not only in the tumor cell growth-related genes and/or tissue-specific genes but also in the body\'s immune response-related genes. Accordingly, there should be multiple

• This hypothesis also provides some insight into more

  2018-10-23

  

  This aa-utp also provides some insight into more pronounced beneficial effects of low alcohol consumption on the risk of AP in women compared to men. Specifically, women are more likely to develop biliary problems and gallstones (Shen et al., 2013; Russell et al., 1998) and therefore constitute a l

• Dengue is a climate sensitive mosquito borne viral disease

  2018-10-23

  

  Dengue is a climate sensitive mosquito-borne viral disease that is generally found in the tropics and subtropics (Murray et al., 2013). According to the World Health Organization (World Health Organization (WHO), 2012) and recent assessment on global burden of diseases (GBD2013) (Murray et al., 2015

• No vaccine induced immune responses were associated with

  2018-10-23

  

  No vaccine-induced immune responses were associated with the zoster events either in targeted immune or whole genome expression studies. This could be due to the absence of appropriate temporal sampling for the transcriptome analyses (no measurements were taken before 14days post-vaccination), or be

• If confirmed in further research

  2018-10-23

  

  If confirmed in further research, our findings may provide an interesting new perspective on the non-specific effects of hsp90 inhibitors and aid global efforts to reduce stunting and related negative health outcomes. Firstly, with regard to stunting, it seems that full and early coverage of vaccin

• Certainly the jury is still out on

  2018-10-23

  

  Certainly the jury is still out on the best way to deliver OVs and arguments can be made for either loco-regional or systemic administration. Indeed the flexibility around delivering OVs by different routes, depending on the clinical setting, may be an advantage over more traditional therapeutic mod

• br Heating Up Immunologically Cold Tumours With an

  2018-10-23

  

  Heating Up Immunologically Cold Tumours With an Oncolytic Virus As discussed our immune systems have evolved elaborate mechanisms to react against invading pathogens and rapidly mount immune responses to eliminate the pathogen and in some instances, the cells they infect. OVs are natural pathogen

• Schizophrenia is also characterized by abnormalities in

  2018-10-23

  

  Schizophrenia is also characterized by abnormalities in the cortical circuitry underlying gamma oscillations elicited by a variety of stimuli and tasks (Uhlhaas et al., 2010). Especially, individuals with schizophrenia exhibit deficits in the auditory steady state response (ASSR) induced by gamma fr

• We also compared protein abundances in

  2018-10-23

  

  We also compared protein abundances in primary Merlin-deficient human meningioma T0901317 against human meningeal cells, and primary human schwannoma cells against primary human Schwann cells. We identified numerous novel upregulated and downregulated proteins and phospho-proteins, performed Gene O

• br Materials and Methods br Results br Discussion Tumors

  2018-10-23

  

  Materials and Methods Results Discussion Tumors of the urinary system were reported to make significant threaten to the overall human cancer burden (Parkin, 2008). A wide variable incidence of urological neoplasms indicates its multi-factorial aetiology that involves the interactions betwee

• br Translating Senolytics into Clinical Treatments

  2018-10-23

  

  Translating Senolytics into Clinical Treatments Healthspan, lifespan, or other very long-term potential endpoints for clinical trials of interventions that target basic aging processes, including SASP-inhibitors or senolytics, would be difficult or next to impossible to study for reasons that are

• br Surface roughness characterisation The surface morphology

  2018-10-23

  

  Surface roughness characterisation The surface morphology was characterised by Atomic Force Microscopy (AFM). The top view of glass, TiO2 compact layer and CH3NH3PbI3 thin film AFM images are shown in Fig. 1. The surface roughness of glass and TiO2 compact layer is negligible compared with CH3NH3

• Specifications table br Value of the data br Experimental

  2018-10-23

  

  Specifications table Value of the data Experimental design, materials and methods The digital camera was attached to light transmission microscope with 10× objective magnification and no eye pieces. The blood smear has been illuminated by 50W halogen lamp and the image focused by normal micro

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