• sglt-2 In Blake Alkire and colleagues now provide

  2019-04-23

  

  In , Blake Alkire and colleagues now provide additional measures to help us gain political priority on the public health agendas. In this study, Alkire and colleagues modelled access to surgery in 180 countries on the basis of four criteria: timeliness, surgical capacity, safety, and affordability.

• This is the first report describing the

  2019-04-23

  

  This is the first report describing the occurrence of HLH in a patient with refractory CLL who had started Ibrutinib treatment. Hemophagocytic lymphohistiocytosis (HLH) is a rare and frequently fatal disorder characterized by an ineffective T-cell and NK response resulting in an exuberant cytokine p

• br As outlined in in October my vision for WHO

  2019-04-23

  

  As outlined in in October, 2016, my vision for WHO can be summed up in five words: equity, rights, responsiveness, evidence, and partnership. In this mek inhibitors context, I am pleased to respond to the authors of the open letter in , on the leadership role that WHO must play in tackling the h

• br In a detailed analysis using multiple data sources in

  2019-04-23

  

  In a detailed analysis using multiple data sources in this issue of , Emily Keats and colleagues show that Kenya made some progress in reducing maternal and newborn mortality between 2003 and 2015, and made greater progress in reducing child mortality between 1998 and 2015, after earlier increases

• Previous health emergencies have shown that it can

  2019-04-22

  

  Previous health emergencies have shown that it can take time to organise global collective action and provide financing to the national and local level. In such situations, a global mechanism should offer a rapid injection of liquidity to affected countries. The World Bank\'s Pandemic Emergency Fina

• Development of an atrial esophageal

  2019-04-22

  

  Development of an atrial–esophageal fistula is one of the most dreaded complications of AF ablation [78]. A relatively large-scale nonrandomized study revealed that the anatomical risk factor of a small LA-to-esophageal distance was the most important factor in esophageal ulceration when using an ir

• br Discussion Over the past two decades the

  2019-04-22

  

  Discussion Over the past two decades, the incidence of second primary malignancy has progressively risen among cancer survivors and is an issue of increasingly greater concern in oncology. The increasing incidence may be due to the elevated rate of early cancer detection, improved cancer treatmen

• wst-1 assay The animal model described here is also expected

  2019-04-22

  

  The animal model described here is also expected to lead us to design mechanism-based therapeutic interventions for bone metastases of NB. In this context, it is notable that the selective COX-2 inhibitor NS-398, which is known to selectively inhibit COX-2 without affecting COX-1 activity [30], inhi

• br Case report Radiographs showed a

  2019-04-22

  

  Case report Radiographs showed a lytic lesion in the left ilium adjacent to the sacroiliac joint (Fig. 1). Computed tomography (CT) (Fig. 2) showed a 5.5×5.0×3.4cm3 lytic lesion in the left ilium; the sacrum was not involved. The lesion was of uniform density with no bone or cartilage matrix form

• br Introduction Bone marrow adipocytes are one of the most

  2019-04-22

  

  Introduction Bone marrow adipocytes are one of the most abundant cell types found in bone marrow tissue. They constitute approximately 15% of the bone marrow volume in young adults, rising to 60% by the age of 65 years old [1]. Previously considered as inert space filling cells with little biolog

• Most forms of AVNRT are created by reentry between two

  2019-04-22

  

  Most forms of AVNRT are created by reentry between two (or more) atrial connections to the AV node. The fast AV nodal pathway (shortest conduction time) is formed by transitional cells crossing the tendon of Todaro superiorly. Two slow AV nodal pathways are formed by the rightward and leftward infer

• No es xito peque o

  2019-04-22

  

  No es éxito pequeño que “bajo la dirección del maestro Stols” (así indica el colofón del libro) se lograse tal parecido con ellas, pero conviene subrayar que Jusep Torres Campalans no es mera mímesis material de la colección Le goût de notre temps sino también, o ante todo, estructural. El Picasso d

• GW788388 br Martyn Plummer and colleagues September analyse

  2019-04-22

  

  Martyn Plummer and colleagues (September, 2016) analyse the global burden of cancers attributable to infections in 2012. Despite the relatively low attributable proportion compared with other infectious agents, liver flukes, including and , were estimated to have caused 1300 new cases of cholangi

• The present study determined the effect of DCA on

  2019-04-22

  

  The present study determined the effect of DCA on VSMC calcification in vitro and in atherosclerotic ApoE-/- mice in vivo. We found that SB525334 non-toxic concentrations of DCA, did not affect VSMC viability, induced calcification of VSMC in culture and increased atherosclerotic vascular calcifica

• br The Medical Education Partnership Initiative MEPI is an i

  2019-04-20

  

  The Medical Education Partnership Initiative (MEPI) is an innovative and potentially transformative 5-year programme, established by the US Government in 2010, to increase the number of doctors to meet crucial human resource needs in sub-Saharan Africa. MEPI allows African institutions that ampa

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