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The specific mutations in the EGFR gene of NSCLC are
2018-10-31
The specific mutations in the EGFR gene of NSCLC are correlated with clinical responsiveness to the TKI gefitinib. These mutations lead to the increase of growth factor signaling and susceptibility to the inhibitor. Such mutations in NSCLC lead to the good response to cetuximab and panitumumab that
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Smyrnovaa and Yuliya conducted a set of experimental
2018-10-31
Smyrnovaa and Yuliya (2010) conducted a set of experimental measurements inside a reverberation chamber using a probe tube for two samples of Buxuc plants from the Buxaceae family. The results for the two set of measurements are shown in Figure 9. According to [ASTM C423], the Sound Absorption Aver
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After Qatar s national independence in
2018-10-31
After Qatar׳s national independence in 1971, the British consultant Llewelyn Davis was appointed by the new town planning authority to design the first master plan of Doha for 1990. His plan was based on a ring concept with a clear definition and a functional distribution of land uses for each ring,
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Introduction In this study the dynamics of
2018-10-31
Introduction In this study, the dynamics of the spatial experience of a Mamluk madrassa and its mausoleum are investigated, and the nature of the configuration rules underlying their annexation over time is examined. Furthermore, answering the questions of whether the madrassa and the mausoleum rem
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Furthermore several animal studies have demonstrated that th
2018-10-31
Furthermore, several animal studies have demonstrated that the injection of IL-6, tumor necrosis factor (TNF)-α, or lipopolysaccharides (which induce IL-1 and TNF-α synthesis) leads to fatigue, decreased life activity, increased somnolence, anorexia, and social withdrawal. These proinflammatory cyto
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br Results The groups had comparable age and sex distributio
2018-10-31
Results The groups had comparable age and sex distributions (p > 0.05). Moreover, both groups exhibited a comparable mean duration of surgery. However, the groups differed significantly in terms of the operative findings (p 0.05; Table 1). In Group A, 60 patients (93.75%) tolerated early feedin
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It is imperative that we
2018-10-31
It is imperative that we develop efficient culture methods that can overcome the obstacles found in the current culture systems. Moreover, new culture methods should be optimized for production of clinically relevant cell numbers, tissue morphogenesis, high-throughput drug discovery, and efficient a
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Because SAPK mediates hyperosmolar stress induced Hand and H
2018-10-31
Because SAPK mediates hyperosmolar stress-induced Hand1 and Hand1-dependent PL1 (Awonuga et al., 2011), we tested whether stress-induced lineage choice during hypoxia was SAPK-dependent. Since hyperosmolar stress induces the first lineage but not later lineages from TSC (Liu et al., 2009), and SAPK
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igf 1 antagonist The present results found that
2018-10-31
The present results found that under osteogenic induction, hydrostatic pressure promoted the igf 1 antagonist of marker genes for early osteogenic differentiation in BMSCs through the activation of RhoA/ROCK. It was reported that the activated RhoA/ROCK proteins enhanced myosin motor activity throu
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With these results we provide evidence that the transplantat
2018-10-31
With these results, we provide evidence that the transplantation of iPSC-derived NSCs could have a beneficial role in modifying the course of SMARD1. Regarding the translational safety of iPSC-derived cells, one major finding of this study is that adverse events such as tumorigenesis or abnormal gro
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Based on our findings and
2018-10-31
Based on our findings and the recent literature, we propose the following model of sebocyte differentiation (Figure 7). First, subsets of LGR6- and LRIG1-expressing calcium ionophore residing in the upper HF and periphery of the SG constitute the bona fide stem cells of the sebocyte lineage (Page e
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Constitutive expression of Puro TK
2018-10-31
Constitutive expression of Puro/TK from the ubiquitously active mPGK promoter might hinder therapeutic applications of this approach. Indeed, these highly immunogenic prokaryotic/viral proteins can be presented on the cell surface of the gene-corrected EHT 1864 by the major histocompatibility comple
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To confirm this we transplanted
2018-10-31
To confirm this, we transplanted mutant order ACA into wild-type hosts in a reverse transplant setting. Either 5 × 105 OsxCre;iDTR mutant or control bone marrow cells, competed with 5 × 105 SJL bone marrow cells in a 1:1 ratio, were transplanted into lethally irradiated SJL hosts. When cells from O
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br The connection between the yield
2018-10-30
The connection between the yield point of a material and the surface tension caspase pathway of its particles As follows from Fig. 1, the surface tension coefficient rapidly decreases with a decrease in the particle size R/δ of the material, for particles with sizes less than 20δ (about 20nm). I
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The morphological features of the MnO modified materials
2018-10-30
The morphological features of the MnO2-modified materials obtained are clearly visible in Figs. 2 and 3 which show the surfaces of these materials, imaged by SEM at different magnifications. It can be seen that high-silica samples (see Fig. 2a) have a monolithic structure, apparently consisting of c
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