• br Conclusion Our goal here is to provide a conceptual

  2018-10-22

  

  Conclusion Our goal here is to provide a conceptual synthesis of key observations that could ultimately be used to underpin computational simulations of ES cell regulatory circuitry using a novel coarse-grained modeling layer. The TF branching process framework avoids the intricacies of molecular

• Introduction Stroke remains a leading cause of adult disabil

  2018-10-22

  

  Introduction Stroke remains a leading cause of adult disability worldwide. In Brazil it is the leading cause of death, with a mortality rate of approximately 51.6 deaths per 100,000 inhabitants (Garcia et al., 2009) and shows the highest case-fatality rate in Latin America (Lotufo and Bensenor, 200

• The aforementioned experiments demonstrated the essential

  2018-10-22

  

  The aforementioned experiments demonstrated the essential roles of Dbr/Hh signaling in midgut homeostasis. Next, we examined the source(s) of Hh involved in this process. We determined hh expression by using an hh-lacZ enhancer and Hh antibody. A high level of Hh expression was found in the anterior

• br Acknowledgments The authors thank

  2018-10-22

  

  Acknowledgments The authors thank Kathryn D. Rodgers for critically reading the manuscript. The authors also thank Anika Voss, Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Germany, for technical assistance. The study was funded by a grant from STORZ Medica

• We recently found that E cad function cannot

  2018-10-22

  

  We recently found that E-cad function cannot be replaced by N-cad during the formation of the trophectoderm, the first polarized epithelium formed during mammalian development. In the blastocyst, the E-cad extracellular domain provides a unique and indispensable survival signal by facilitating Igf1r

• n-acetyl-l-cysteine The characteristics or molecular mechani

  2018-10-20

  

  The characteristics or molecular mechanisms by which mESCs maintain self-renewal or pluripotency have been determined: mESCs have high alkaline phosphatase (AP) activity, form tightly aggregated, three-dimensional colonies, and maintain their pluripotent character by stable expression of core plurip

• The first initiating event that starts

  2018-10-20

  

  The first initiating event that starts the process of tumorigenesis must originate in a healthy cell. It is possible that this healthy cell may not be a stem cell (O\'Brien et al., 2007). However, given any cell of a healthy self-renewing tissue, the number of divisions that separates this cell from

• br Conclusions br Authors contribution

  2018-10-20

  

  Conclusions Authors\' contribution Acknowledgments This work was supported by grants from the Newlife Foundation (grant 12-13/20), the Great Ormond Street Hospital Children\'s Charity (grant V1234), the Antony Nolan Trust, and a studentship to CAG from Consejo Nacional de Ciencia y Tecnolog

• janus kinase br Resource table Resource details Following th

  2018-10-20

  

  Resource table: Resource details Following their mechanical isolation from day 7 blastocysts, the inner cell masses (ICM) were seeded individually onto the feeder layers. After 2days of incubation, most of the ICMs were found attached to the feeder cells. The cultures were allowed to grow for 8–

• In addition to PES pre treatment increasing HPC adhesion

  2018-10-20

  

  In addition to PES pre-treatment increasing HPC7 adhesion within the colon, it also concomitantly reduced pulmonary presence, thereby reducing non-specific retention in healthy tissues. Pulmonary entrapment is a major obstacle for systemic HSPC delivery for regenerative purposes both experimentally

• In the current study we compared

  2018-10-20

  

  In the current study, we compared two different genetic backgrounds on the induction and maintenance of multipotency by generating clonal iNSC lines from two distinct mouse strains (C57BL/6 vs. C3H). Clonal iNSC lines from distinct genetic backgrounds exhibited the distinct levels of conversion effi

• Induction of EndMT results from integration of

  2018-10-20

  

  Induction of EndMT results from integration of multiple extrinsic inputs within the dynamically shifting cellular environment of cardiogenesis. Owing to the membrane bound presentation of ligands, Notch signaling status is dependent on the organization and distribution of signal-presenting and signa

• The karyotype of the BIOT EHMT iPSC line

  2018-10-20

  

  The karyotype of the BIOT-0708-EHMT1 iPSC line was determined with Giemsa-banding, proving normal diploid 46, XX karyotype, without any detectable abnormalities (Fig. 1B). In parallel, the pathogenic NM_024757.4(EHMT1):c.3413G>A mutation was confirmed by Sanger sequencing in the newly established iP

• Also critical to the success of hard tissue engineering stra

  2018-10-20

  

  Also critical to the success of hard tissue engineering strategies is the selection and use of an appropriate growth factor regimen. Although several growth factors are reported to play an important role in the process of matrix mineralisation, IGF-1 is the most abundant growth factor in bone matrix

• Previously we showed that the

  2018-10-20

  

  Previously, we showed that the transcription factor SLUG is an important regulator of mammary epithelial lineage commitment and differentiation (Proia et al., 2011). Recent studies have also shown that SLUG is necessary for the mammary stem cell state (Guo et al., 2012). However, SLUG-deficient mice

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