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br Use of recombinant collagen to study DDR collagen interac
2020-04-10
Use of recombinant collagen to study DDR–collagen interactions Synthetic peptides have proven highly valuable in replicating the characteristics of collagen and in defining the sites on collagen essential for binding and studying protein–collagen interactions. There are, however, disadvantages to
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The discoidin domain receptors DDR and DDR are receptor
2020-04-10
The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases (RTKs) that are stimulated by collagen in the extracellular matrix (ECM). Unlike most other RTKs, they form ligand-independent stable dimers that are non-covalently linked. This ECM activation induces receptor phosphorylati
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A growing body of data indicates that endothelial NOS eNOS
2020-04-10
A growing body of data indicates that endothelial NOS (eNOS) is a rate-limiting enzyme for the synthesis of nitric oxide (NO), its downstream GYY 4137 morpholine salt molecule. High pathological concentrations of NO produced from inducible NO synthase (iNOS) induce apoptosis, whereas a reduction in
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br Acknowledgements The present study was supported by
2020-04-10
Acknowledgements The present study was supported by the Medical Science and Technology Program of Zhejiang Province2014KYA228 (Zhijun Zhou), 2016KYA195 (Jie Li) and 2017KY714 (Qingqing Xia); Zhejiang Provincial Natural Science Foundation of ChinaQ17H120001 (Jie Li); and Scientific Research Projec
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Recently a method for in vivo photoactivation of
2020-04-10
Recently, a method for in vivo photoactivation of CGP 3466B maleate expressing PA-GFP in precise microanatomical compartments was described (Victora et al., 2010), which makes it possible to optically mark Tfh cells and track them 20 hr later (Shulman et al., 2013). Unexpectedly, it was reported th
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Concholepas concholepas our model species for this study is
2020-04-10
Concholepas concholepas, our model species for this study, is a marine gastropod found along the Chilean coast that has become commercially important [25], [26], [27]. Until now, the main focus of immunology related to C. concholepas is the production of a novel hemocyanin that has been useful for t
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PGE exerts its functions by binding to different
2020-04-10
PGE2 exerts its functions by binding to different receptors. Four different subtypes of PGE2 receptors are found in mammals and are designated as EP1-4. These are G-protein coupled receptors that belong to a family of seven rhodopsin-like transmembrane spanning receptors. They are structurally diffe
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Enzyme mimics belong to a type of rising
2020-04-10
Enzyme mimics belong to a type of rising catalysts which show the similar function with their corresponding natural enzymes [20], [21], [22], [23], [24], [25], [26], [27], although their structures are different from natural enzymes. In the area of prodrug activation, the widely-used enzyme mimics a
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Autophagy alterations are frequently reported as one of
2020-04-10
Autophagy alterations are frequently reported as one of the pathological mechanisms contributing to neurodegenerative diseases, due to incomplete removal of protein Urolithin A in the brain [30,41]. It was over a decade ago when mutations in PARK8 encoding for the LRRK2 protein were described as a m
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PF-CBP1 hydrochloride Uracil residues incorporated into DNA
2020-04-09
Uracil residues incorporated into DNA exist transiently since they are subject to removal by the multi-step uracil-initiated DNA PF-CBP1 hydrochloride excision repair (BER) process [2], [14]. In E. coli, uracil-DNA BER is initiated by uracil-DNA glycosylase (Ung), which catalyzes the hydrolytic clea
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TgTCEA from petals TgTCEA and TgTCEB from
2020-04-09
TgTCEA from petals (TgTCEA1) and TgTCEB from pollen grains (TgTCEB1) were used throughout the study. The recombinant enzymes were expressed in , and purified as the His-tag-free forms as described previously., Enzyme reactions were performed at 4 mM substrates under the same conditions as described
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Studies using SERPINB deficient mice established the signifi
2020-04-09
Studies using SERPINB1-deficient mice established the significant role for SERPINB1 in protecting lung antimicrobial proteins from proteolysis during microbe infection and its regulatory role in sustaining the balance of neutrophil reserve [15]. Neutrophil serine proteases (NSPs) (elastase, cathepsi
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We report here that ESCL protein
2020-04-09
We report here that ESCL protein exhibits a temporal expression profile that is complementary to that of ESC, including substantially higher levels of expression during larval and adult stages than embryogenesis. We show that ESCL, like ESC, binds directly to E(Z) via its WD repeats and is physicall
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Penciclovir Sodium synthesis Accumulating evidence suggests
2020-04-09
Accumulating evidence suggests that certain abnormal emotional traits, such as impulsive aggression and cluster B personality, are associated with suicidal behaviors (Currier and Mann, 2008, Mann et al., 2009, Rujescu et al., 2007, Turecki, 2005). Impulsive aggression appeared to be associated with
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br Multi subunit RINGs There are RING
2020-04-09
Multi-subunit RINGs There are RING-type E3s that exist as multi-subunit assemblies (see Fig. 3B). A striking example is the Cullin RING Ligase (CRL) superfamily [35], which exhibits enormous plasticity in substrate specificity. Each CRL subfamily is characterized by a cullin protein (Cul-1, 2, 3,
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