• The renin angiotensin system RAS is

  2023-05-17

  

  The renin-angiotensin system (RAS) is a hormonal system which plays a role in the regulation of blood pressure and body fluid BCECF-AM [14]. The main bioactive peptide of RAS is angiotensin II (Ang II) whose biological functions are interposed through angiotensin type 1 receptor (AT1R) and angioten

• The androgen receptor gene AR is

  2023-05-17

  

  The androgen receptor gene (AR) is located on the X-chromosome and consists of eight exons in humans (Brown et al., 1989; Kuiper et al., 1989). The similar gene structure in mice, monotremes and marsupials indicates AR is highly conserved in mammals (Choong et al., 1998; Faber et al., 1991; He et al

• br Experimental procedures br Results br Discussion br Ackno

  2023-05-15

  

  Experimental procedures Results Discussion Acknowledgments Introduction β-Adrenergic receptors (β-ARs) belong to the superfamily of membrane proteins termed G protein-coupled receptors. β-ARs are distributed in the effector GSK1210151A of most of the sympathetic nerve fibers, and the

• br Conclusion br Conflict of Interest br Author

  2023-05-15

  

  Conclusion Conflict of Interest Author Contributions Acknowledgements This work was supported by a research grant (SR/50/AS-14/2012) from the Department of Science and Technology, New Delhi, India to CMC and CSIR Senior Research Fellowship (09/013(0339)/2010-EMR-I) to SB. Introduction

• The obtained results indicate that even

  2023-05-15

  

  The obtained results indicate that even when the impairment of the same forms of memory are present, amnesia can develop in different ways. Impairment of memory reconsolidation in the conditioned food aversion model through both the serotonin receptor antagonist and the antagonist of NMDA glutamate

• Introduction Dementia is a common disease in the elderly and

  2023-05-15

  

  Introduction Dementia is a common disease in the elderly, and a significant source of disability, healthcare spending, and long-term care admissions. There is evidence to suggest that testosterone plays a role in cognitive functioning, and lower serum levels correlate with higher amyloid deposits (

• While the yeasts and see Glossary each contain only one

  2023-05-15

  

  While the yeasts and (see Glossary) each contain only one Aurora homolog, Ipl1p (increase in ploidy 1) and Ark1 (Aurora-related kinase 1), respectively 5, 6, , and Xenopus laevis contain two Aurora kinases: Aurora A and Aurora B [4]. Mammals have three Aurora kinases, A, B, and C (Figure 1). In an

• Although the LB domains of mGlu receptors have not been

  2023-05-15

  

  Although the LB2 domains of mGlu receptors have not been shown to form an extensive interface during activation, they do draw closer to each other, as demonstrated in crystal structures (Kunishima et al., 2000, Muto et al., 2007, Tsuchiya et al., 2002) and by FRET analysis (Doumazane et al., 2013, V

• br Physiology of the apelin pathway br Role of apelin

  2023-05-15

  

  Physiology of the apelin pathway Role of apelin in heart disease Both apelin and apelin receptor null mice manifested moderate reduction in cardiac contractile function under basal conditions and their exercise capacity was markedly reduced (Table 1) [56]. Apelin has direct effects on the prop

• br The role of apelin in

  2023-05-15

  

  The role of apelin in cancer Studies on cancers are intensively conducted worldwide. It is thought that this large family of diseases is among the most studied. The researchers test newly-discovered substances hoping to find remedies and diagnostic indices for this illness. One of such substances

• br Experimental methods br Acknowledgments

  2023-05-15

  

  Experimental methods Acknowledgments Introduction Long-term potentiation (LTP) and long-term depression (LTD) at excitatory synapses are thought to underlie experience-dependent learning and memory. These synaptic plasticity mechanisms are best characterized at hippocampal CA1 synapses, whe

• Our conclusion was confirmed by two experiments The

  2023-05-15

  

  Our conclusion was confirmed by two experiments. The addition of aminopeptidase-specific inhibitors at high concentrations allowed us to exclude the possibility of substrate hydrolysis by other proteases present in the samples, for example, endoproteases. After the application of inhibitors, we were

• br Introduction The chronic inflammation is one of

  2023-05-12

  

  Introduction The chronic inflammation is one of the leading events involved in the aetiology of many chronic-degenerative diseases including diabetes, atherosclerosis, arthritis and cancer (Coussens and Werb, 2002). Monocytes/macrophages lineage plays an important role during inflammation through

• The initial observations indicating a crucial role for elect

  2023-05-09

  

  The initial observations indicating a crucial role for s3i mg transfer in 17,20 lyase activity were that the molar ratio of POR to P450c17 is three- to four-fold higher in porcine testes than in porcine adrenals, and that adding purified POR to porcine P450c17 in vitro increased 17,20 lyase more th

• Drug resistance development often involves structurally

  2023-05-09

  

  Drug resistance development often involves structurally un-related drugs and, specifically both conventional and targeted agents. IGROV-1/Pt1 SB-334867 free base are characterized by resistance to cisplatin and reduced sensitivity to inhibitors of EGF-R and MEK, the up-stream activator of ERK1/2, a

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